ACTRN12624000873527尚未招募Unknown
The CASSOWARY (CAncer genomic riSk ScOres in primARY Care) Trial: a randomised controlled trial of the clinical utility and cost-effectiveness of a multi-cancer polygenic risk score in general practice
niversity of Melbourne0 个研究点目标入组 392 人开始时间: 2024年7月17日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 392
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Diagnosis
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 40 Years 至 59 Years（—）
- 性别
- All
入选标准
- •Are aged between 40 and 59 years
- •Are able to read and write English and competent to give informed consent
- •Are contactable over the next 12 months for trial follow-up
排除标准
- •Have been diagnosed with any of breast, prostate, colorectal cancer or melanoma;
- •Have any alarm symptoms that are potentially indicative of any cancer:
- •Once or more and not investigated:
- •Blood in stool or urine
- •For more than four weeks and not investigated:
- •Problems with urination
- •Unexplained weight loss
- •An unusual pain, lump or swelling anywhere in the body
- •A new or changed spot on the skin;
- •Have a known genetic predisposition to any of the four cancers in question or, a first-/second-degree relative with a genetic predisposition and the participants has not had genetic testing themselves. This includes (but is not limited to) by a pathogenic variant in any of the following genes:
- •CRC: Lynch syndrome (MLH1, PMS2, MSH2, MSH6, EPCAM), familial adenomatous polyposis (APC);
- •BrCa: BRCA1, BRCA2, PALB2, ATM, CHEK2;
- •PrCa: BRCA1, BRCA2, HOXB13;
- •Melanoma: CDKN2A/p16.
- •Have any health condition or illness that, in the opinion of the participant or researcher, would impact their appropriateness for cancer screening or their ability to participate
研究者
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