NCT02459132已完成不适用
A Phase II Randomized Trial of High-Intensity Aerobic Interval Training and Surrogate Markers of Cardiovascular Disease in a Population-based Sample of Testicular Cancer Survivors
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 主要终点
- Peak aerobic capacity (relative VO2peak)
研究概览
简要总结
This study evaluates the impact of a supervised 12-week high-intensity aerobic interval exercise program (versus a self-directed exercise usual care group) on traditional and novel cardiovascular disease risk factors and surrogate markers of cardiovascular- and overall-mortality in a population-based sample of testicular cancer survivors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •histologically confirmed history of testicular cancer
排除标准
- •Not sufficiently ambulatory to complete the first two stages of the aerobic exercise test.
- •Have a psychiatric condition which impairs their ability to perform the required volume and intensity of exercise.
- •Have any uncontrolled cardiovascular condition (i.e. heart disease, hypertension, diabetes, arrhythmia).
- •Report performing any weekly vigorous intensity aerobic exercise in the past month.
结局指标
主要结局
Peak aerobic capacity (relative VO2peak)
时间窗: Baseline and within 7 days of completing the 12-week intervention
ml O2/kg/min
次要结局
- Peak aerobic capacity (absolute VO2peak)(Baseline and within 7 days of completing the 12-week intervention)
- Postexercise 1-minute heart rate recovery(Baseline and within 7 days of completing the 12-week intervention)
- Average carotid intima-media thickness(Baseline and within 7 days of completing the 12-week intervention)
- Carotid distensibility(Baseline and within 7 days of completing the 12-week intervention)
- Velocity time integral(Baseline and within 7 days of completing the 12-week intervention)
- Respiratory sinus arrhythmia(Baseline and within 7 days of completing the 12-week intervention)
- Diastolic blood pressure(Baseline and within 7 days of completing the 12-week intervention)
- Brachial diameter(Baseline and within 7 days of completing the 12-week intervention)
- Maximal carotid intima-media thickness(Baseline and within 7 days of completing the 12-week intervention)
- Carotid diameter(Baseline and within 7 days of completing the 12-week intervention)
- Brachial flow-mediated dilation(Baseline and within 7 days of completing the 12-week intervention)
- Heart rate(Baseline and within 7 days of completing the 12-week intervention)
- Systolic blood pressure(Baseline and within 7 days of completing the 12-week intervention)
- Femoral-toe pulse wave velocity(Baseline and within 7 days of completing the 12-week intervention)
- Low-density lipoprotein(Baseline and within 7 days of completing the 12-week intervention)
- Total cholesterol : high-density lipoprotein ratio(Baseline and within 7 days of completing the 12-week intervention)
- Vascular age(Baseline and within 7 days of completing the 12-week intervention)
- Carotid-femoral pulse wave velocity(Baseline and within 7 days of completing the 12-week intervention)
- Fibrinogen(Baseline and within 7 days of completing the 12-week intervention)
- Total cholesterol(Baseline and within 7 days of completing the 12-week intervention)
- Triglycerides(Baseline and within 7 days of completing the 12-week intervention)
- Shear stress during reactive hyperemia(Baseline and within 7 days of completing the 12-week intervention)
- High-density lipoprotein(Baseline and within 7 days of completing the 12-week intervention)
- Testosterone(Baseline and within 7 days of completing the 12-week intervention)
- Framingham Risk Score(Baseline and within 7 days of completing the 12-week intervention)
- High-sensitivity C-reactive protein(Baseline and within 7 days of completing the 12-week intervention)
- Fasting glucose(Baseline and within 7 days of completing the 12-week intervention)
- Modifiable CVD Risk Factor Score(Baseline and within 7 days of completing the 12-week intervention)
研究者
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