The Impact of Aspirin and Clopidogrel on Brain-derived Neurotrophic Factor (BDNF) Concentrations in Human Serum and Plasma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- BDNF plasma and serum concentration 24 hours after Aspirin or Clopidgrel intake
研究概览
简要总结
The impact of anti-platelet drugs on the concentrations of Brain-derived neurotrophic factor (BDNF) in human plasma and serum is unknown. It is the aim of this study to investigate the impact of a single dose of Aspirin (500 mg) or Clopdigrel (600 mg) on the concentrations of Brain-derived neurotrophic factor (BDNF) in plasma and serum of healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 18-50 years
- •Gender: Male
排除标准
- •Any acute disease
- •Any chronic disease
- •Any medication
- •Allergies / Intolerance in association with Aspirin or Clopidogrel
研究组 & 干预措施
A
Intake of 500 mg Aspirin on day 1. Intake of 600 mg Clopidogrel on day 28. Measurement of platelet inhibition, platelet counts and BDNF, TGF-beta, 5-HT concentrations in peripheral blood on day 1 (before intake of 500 mg Aspirin), day 2 (24 hours after intake of 500 mg Aspirin), day 28 (before intake of 600 mg Clopidogrel), day 29 (24 hours after intake of 600 mg Clopidogrel).
干预措施: Aspirin and Clopidogrel (Drug)
结局指标
主要结局
BDNF plasma and serum concentration 24 hours after Aspirin or Clopidgrel intake
时间窗: 24 hours
次要结局
- 5-HT and TGF-beta concentrations 24 hours after Aspirin or Clopidgrel intake(24 hours)