The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Chronic Periodontitis - A Comparative Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- Serum levels of TRAP-5b
研究概览
简要总结
To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.
详细描述
30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days.
Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Presence of atleast 20 teeth
- •more than 30% of sites with clinical attachment loss of ≥ 5 mm
- •non-smokers
- •no previous history of periodontal therapy
排除标准
- •systemic diseases
- •under antibiotics or anti-inflammatory drugs within previous 3 months
- •pregnant and lactating women
- •allergic to antibiotics
研究组 & 干预措施
Group A -control group
15 subjects underwent scaling and root planing
干预措施: Scaling and root planing (Procedure)
Group B-Interventional group
15 subjects underwent scaling and root planing along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days
干预措施: scaling and root planing along with antibiotic intervention (Drug)
结局指标
主要结局
Serum levels of TRAP-5b
时间窗: Baseline and 3 months
Concentration of serum levels of TRAP-5b was assessed at baseline and at 3rd month using ELISA method.
次要结局
- Clinical attachment level(Baseline and 3 months)
- Probing pocket depth(Baseline and 3 months)
研究者
Dr.Jaideep Mahendra
Professor
Meenakshi Ammal Dental College and Hospital