NCT04206033已完成不适用
Hemophilia and Bone Metabolism: Study of Monocytic Populations and Inflammatory Proteins
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- To study the monocytic populations possibly involved in bone metabolism in hemophiliac patients.
研究概览
简要总结
The investigators propose, as part of the study, to carry out for each patient:
- An analysis of monocytic populations by flow cytometry (CD14, CD16, CD45, CD68, CD115, CCR2, CX3CR1, CD163 and CD206).
- A population assessment of Myeloid-Derived Suppressor Cells (MDSC).
- Assays of cytokines and chemokines involved in inflammation by multiplex analyzes: Il-1 (α and β), Il-4, Il-6, Il-10, Il-13, TNF- α, TGF- β, CRP , leptin, IFN- β.
- Specialized dosages of proteins involved in bone metabolism. RANKL, osteoprotegerin, M-CSF, TRAPCP5.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Major patients followed at the hemophilia treatment reference center,
- •Presenting the diagnosis of severe, moderate or minor Hemophilia A / B,
- •Having a social security system,
- •Obtaining the oral non-objection collection from the patient after information.
排除标准
- •Minor patients, under guardianship or curatorship.
- •Causes of secondary osteoporosis:
- •Systemic corticosteroid therapy in progress (≥ 3 consecutive months, at a dosage ≥ 7.5 mg / d of prednisone equivalent).
- •other treatment or condition responsible for osteoporosis: prolonged or medicated hypogonadism, untreated active hyperthyroidism, hypercorticism, primary hyperparathyroidism.
- •Treatment with biphosphonates, biotherapies or hormone therapy in the treatment of prostate cancer.
结局指标
主要结局
To study the monocytic populations possibly involved in bone metabolism in hemophiliac patients.
时间窗: 1 year
Evaluation of the inflammatory profile of patients by protein assays
次要结局
- Find a correlation between the main objective and the measurement of bone density(1 year)
- Look for a correlation between the main objective and physical activity(1 year)
- Look for a correlation between the main objective and the inflammatory profile in hemophiliac patients.(1 year)
研究者
研究点 (1)
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