Risk and Social Feedback in Adolescents With Nonsuicidal Self-Injury
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Risky avoidance measured by BART
研究概览
简要总结
Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Problematic interpersonal relationships and decision-making have been demonstrated to play crucial roles in this maladaptive behavior, especially for adolescents. Accumulating evidence suggests that decision processes and risk-taking are strongly influenced by the affective state of the individual. However, whether these interactions are disrupted in NSSI adolescents has not been systematically examined. In the current study, the investigators modified one of the most widely used paradigms for measuring an individual's risk decision-making, the Balloon Analogue Risk Task (BART). The investigators combine social reward (green balloon), punishment (red balloon), and control feedback (yellow balloon), to investigate whether the NSSI adolescents have dysfunctional risk-taking behavior while facing different social outcomes. The investigators recruit one group of NSSI adolescents (n = 40) and one health control (HC) group (n = 40), to compare their risk-related decisions during the emotional BART. The investigators hypothesize that compared to HC, NSSI adolescents will show altered effects of social reward and punishment on risk-related decision-making, in particular higher risk avoidance in the context of social punishment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 15 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •15-18 years
- •right-handed
- •normal or corrected normal visual acuity
- •meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)
排除标准
- •diagnosis of borderline personality disorder, major depressive disorder, other
- •psychiatric disorders, etc.
- •high suicidal risk
- •recent use of medications that can affect neural activity
- •have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
- •have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)
结局指标
主要结局
Risky avoidance measured by BART
时间窗: About 20 minutes
Adjusted number of pumps (average number of pumps excluding balloons that exploded) as the index of risk avoidance. Alterations in the patients will be determined by using ANOVA models with the group (NSSI vs. HC) as a between-subject factor and emotional feedback (social reward, social punishment, and control) as a within-subject factor.
Decision-making measured by BART
时间窗: About 20 minutes
Earned money (total amount of money earned in the task) as the index of decision-making. Alterations in the patients will be determined by using ANOVA models with the group (NSSI vs. HC) as a between-subject factor and emotional feedback (social reward, social punishment, and control) as a within-subject factor.
次要结局
未报告次要终点
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China