Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Variation (%) of the amplitudes of the electric shock
研究概览
简要总结
Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory.
The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:
- A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that,
- Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race.
According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.
详细描述
Thus, the main purpose of the present project is to investigate whether sex differences in neuromuscular fatigue in plantar flexors depend on the distance (> 100 km vs < 60 km).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject listed in the race "2019 Mont Blanc Ultra Trail"
- •Affiliates or beneficiaries of social security scheme
- •Signed consent
排除标准
- •Subject having been injured in the previous 3 months
- •Pregnant woman
- •Chronic joint diseases
- •Chronic or central neurological pathologies
- •Taking neuroactive substances that can alter corticospinal excitability
- •Contraindication to experimental procedures including Transcranial Magnetic Stimulation (TMS)
- •Taking corticosteroids in the previous 3 months
结局指标
主要结局
Variation (%) of the amplitudes of the electric shock
时间窗: 5 or 6 day before the race and 1 hour after
Measured by the electrically evoked force after contraction in isometric mode of the plantar flexors
次要结局
- C reactive protein (CRP) (mg/L)(5 or 6 day before the race and 1 hour after)
- Blood viscosity(5 or 6 day before the race and 1 hour after)
- urea (g/L)(5 or 6 day before the race and 1 hour after)
- Electrically evoked forces(5 or 6 day before the race and 1 hour after)
- Voluntary maximum forces plantar flexors(5 or 6 day before the race and 1 hour after)
- Voluntary maximum forces knee extensors(5 or 6 day before the race and 1 hour after)
- Three-Modality Evoked Potentials (TMEPs)(5 or 6 day before the race and 1 hour after)
- Force/Velocity Profile (FVP)(5 or 6 day before the race and 1 hour after)
- ElectroMyoGraphic activity (EMG)(5 or 6 day before the race and 1 hour after)
- Number of red blood cell(5 or 6 day before the race and 1 hour after)
- Transcranial Magnetic Stimulation (TMS)(5 or 6 day before the race and 1 hour after)
- Number of platelets(5 or 6 day before the race and 1 hour after)
- Rate of hemoglobin (%)(5 or 6 day before the race and 1 hour after)
- creatinine (mg/L)(5 or 6 day before the race and 1 hour after)
- Number of white blood cells(5 or 6 day before the race and 1 hour after)
- lactate (mg/L)(5 or 6 day before the race and 1 hour after)
- uric acid (mg/L)(5 or 6 day before the race and 1 hour after)
- Kinematic variable(5 or 6 day before the race and 1 hour after)
- Proteinuria-density urinary (mg/24h)(5 or 6 day before the race and 1 hour after)