Pulmonary surfactant (S) biology in ventilated children on a paediatric intensive care unit with acute (A) hypoxic respiratory (R) failure- a pilot (P) study (S): (SARPS) - SARPS

Southampton University Hospital NHS Trust0 个研究点开始时间: 2011年1月4日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•Inclusion criteria
•Age less than 16 years
•Ventilated on PICU (controls and cases)
•CASES: Acute hypoxic respiratory failure (AHRF) (controls) as defined by degree of observed hypoxia assessed using the P/F ratio P/F ratio of < 300 mmHg (Calculated by dividing the arterial partial pressure of oxygen (PaO2 = P) by the fractional concentration of oxygen in the inspired gas mixture delivered by the ventilator (FiO2 = F)
•CONTROLS: Ventilated children who do not meet the criteria for AHRF as defined above
•Informed consent from the child's parents
•Are the trial subjects under 18? yes
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion criteria
•Failure to obtain informed consent from the child's parents
•Extreme cardiovascular instability
•Intractable intra cranial hypertension
•Pulmonary haemorrhages
•Persistent pulmonary air leak
•Advanced malignancy
•Cardiopulmonary resuscitation
•Children not likely to survive the time period of the intervention
•Patients who are pregnant
•Immediate families of investigators or site personnel directly affiliated with the study. Immediate family is defined as child or sibling, whether biological or legally adopted.
•Participation in a investigational clinical trial

发起方

Southampton University Hospital NHS Trust