Effect of Three Weeks Consumption of Rye Porridge Breakfast on 24 h Appetite Profile, and Acute Effect on OCTT and Breath Hydrogen
试验速览
- 阶段
- 不适用
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Appetite profile
研究概览
简要总结
Acute hunger-reducing effects (8h) has been documented for rye porridge breakfast compared with iso-caloric referenced refined wheat reference breakfast. The primary aim of the current study is to investigate whether this effects remains at regular consumption. A secondary aim is to compare the orocecal transit time (OCTT) between the two breakfasts.
详细描述
The study is randomised and cross-over. During two 3-wk periods, separated by a 3-4-wks wash out, subjects will consume test breakfasts. During one of the periods test breakfast includes rye flake porridge and during the other period test breakfast include bread made from sifted wheat. The breakfast meals will be similar in calorie-, protein-, carbohydrate- and fat content. For all other days but 1, 8 and 22 of respective test period, the breakfast foods will be handed out to the participants along with instructions to exchange their ordinary breakfast with the test foods. During day 1, 8 and 22 the breakfasts will be served at the study centre.
Following measurements will be made:
- Subjective ratings of hunger, satiety and desire to eat during 24 h after breakfast on day 1, 8 and 22 during each 3-wk intervention period.
- on day 8 during each intervention period, orocecal transit time and breath hydrogen will be measured after intake of the breakfast.
- 3 day weighed food diaries will be taken at three occasions: at baseline and during the second week of each dietary intervention period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •man or woman aged between 20 and 60 years;
- •body mass index (BMI) 18-27 kg/m2;
- •habit of consuming breakfast, lunch and dinner every day;
- •and willingness to comply with the study procedures.
排除标准
- •intake of medicine likely to affect appetite or food intake;
- •any medical condition involving the gastrointestinal tract;
- •eating disorder;
- •consumption of more than three cups of coffee per day;
- •change in body weight more than 10% during three months prior to screening;
- •consumption of any restricted diet such as vegan, gluten-free, slimming;
- •pregnancy, lactation or wish to become pregnant during the study period;
- •any known intolerance towards salazopyrin and similar substances
结局指标
主要结局
Appetite profile
时间窗: 24 h
Subjective feelings of appetite (hunger, satiety and desire to eat) were assessed every 30 min, starting just before breakfast at 08:00 and continuing until bedtime. The last recording was made before breakfast on the following day.
次要结局
- energy intake(3 days)
- Orocecal transit time(8 h)
- Breath hydrogen(8 h)