The Role of Continuous Low Serratus Anterior Plane Block in Hepatocellular Carcinoma Surgery: a Randomised Clinical Trial.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- visual analogue scale
研究概览
简要总结
To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.
详细描述
METHODS: Patients with hepatocellular carcinoma who attended our hospital from January 2021 to April 2023 were divided into CS group and N group according to the random number table method; CS group underwent ultrasound-guided continuous low anterior serratus plane block and N group underwent ultrasound-guided single anterior serratus plane block combined with rectus abdominis sheath block; the operation time, anesthesia time, incision length, sensory block time and sensory block maintenance time were counted and recorded. Pain score (NRS) was used to detect analgesia; alanine aminotransferase (ALT), liver function aspartate aminotransferase (AST), and prothrombin time (The time of thrombin, NRS) were measured by fluorescent quantitative PCR. （The time of thrombin (APTT), total bilirubin (TBIL) levels and adverse reactions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-60 years;
- •BMI: 18-29 kg/m2
排除标准
- •Combined cardiac, cerebral, hepatic, and renal failure;
- •Comorbid psychiatric and neuromuscular disorders;
- •A history of allergy to anesthetic drugs;
- •Participation in other recent clinical or drug trials.
研究组 & 干预措施
Continuous serratus anterior plane block
Ultrasound-guided continuous serratus anterior plane block.
干预措施: Ultrasound-guided continuous low serratus anterior plane block (Procedure)
Single serratus anterior plane block combined with rectus sheath nerve block
Ultrasound-guided single serratus anterior plane block combined with rectus sheath nerve block.
干预措施: Ultrasound-guided single serratus anterior plane block (Procedure)
结局指标
主要结局
visual analogue scale
时间窗: 36 hours after surgery.
The visual analogue scale (VAS) of the patient's pain was recorded 36 hours after operation.
Block plane
时间窗: 30 minute after the surgery begins
The effect of anesthesia after ultrasound-guided nerve block was measured using planimetry, as well as the area being anesthetized. The chest wall between T2-T9 and ice cotton balls was used to assess the extent and extent of anesthesia block.
visual analogue scale
时间窗: 24 hours after surgery
The visual analogue scale (VAS) of the patient's pain was recorded 24 hours after operation.
visual analogue scale
时间窗: 48 hours after surgery.
The visual analogue scale (VAS) of the patient's pain was recorded 48 hours after operation.
次要结局
- Intraoperative blood pressure changes(2 hours after the beginning of surgery.)
- Patient satisfaction(48 hours after surgery.)
- Remedial analgesic drug(24 hours after surgery.)
- Intraoperative heart rate changes(2 hours after the beginning of surgery.)
研究者
Liu Di
Principal Investigator
The First People's Hospital of Neijiang