Comparison of Nebulised Dexmedetomidine Versus Nebulised Saline Preoperatively To Attenuate Hemodynamic Response to Laryngoscopy and Endotracheal Intubation: A Randomised Control Trial
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- change in mean artirial pressure and heart rate after lyrangoscopy and intubation
研究概览
简要总结
BLUNTING OF HEMODYNAMIC RESPONSE WILL BE OBSERVED IN PATIENTS NEBULISED WITH DEXMEDETOMIDINE AND NORMAL SALINE.
详细描述
ONE GROUP OF PTS WILL BE NEBULISED WITH DEXMEDETOMIDINE AND OTHER WITH NORMAL SALINE AND WILL BE OBSERVED DURING AND AFTER INTUBATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE FOR LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Participants were blinded to treatment allocation. Treatment was placed in sealed opaque envelopes and selected randomly. The outcome assessor who recorded blood pressure and heart rate was blinded to group allocation to minimize observer bias.
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-60 years
- •Either gender
- •ASA Physical Status I and II
- •Mallampati airway class I and II
- •BMI 18-30 kg/m2
- •Patients undergoing elective surgery under general anesthesia
排除标准
- •Patient refusal or lack of consent
- •Anticipated difficult airway
- •Intubation attempt lasting more than 15 seconds
- •Uncontrolled hypertension, cardiac, pulmonary, hepatic, or cerebral events
- •Known allergy to dexmedetomidine or study drugs
研究组 & 干预措施
nebulised dexmedetomidine
participants will receive nebulised dexmedetomidine 1 microgram/kg diluted in 5ml normal saline via nebulised over 5 minutes, administered 30 minutes before induction of anesthesia. standard monitoring of hemodynamic parameters will be done at baseline, 1 minute and 3 minutes post-intubation
干预措施: Dexmeditomidine (Drug)
nebulised saline
participants will receive nebulised 5ml normal saline via nebulised over 5 minutes, administered 30 minutes before induction of anesthesia. standard monitoring of hemodynamic parameters will be done at baseline, 1 minute and 3 minutes post-intubation.
干预措施: Normal Saline (0.9% Sodium Chloride) (Drug)
结局指标
主要结局
change in mean artirial pressure and heart rate after lyrangoscopy and intubation
时间窗: baseline, 1 minute and 3 minute post intubation
hemodynamic stress response measured as change in mean arterial pressure and heart rate from baseline. MAP and HR will be recorded at baseline T0, 1 minute post intubation T1 ans 3 minute post intubation T3. Significant stress response is defined as rise in MAP nad HR more than 10% of baseline at 3 minutes post intubation.
次要结局
未报告次要终点
研究者
BATOOL ZEHRA
BZEHRA
Shaheed Mohtarma Benazir Bhutto Institue of Trauma