NCT01911689已完成不适用
Magnetic Resonance Imaging Study of Acute Pancreatitis
Affiliated Hospital of North Sichuan Medical College1 个研究点 分布在 1 个国家目标入组 168 人开始时间: 2013年8月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- The T2* Values in the Diagnosis of AP
研究概览
简要总结
To quantitatively analyze the T2* values of the head, body, and tail of normal pancreas, and observe the value of GRE T2*-weighted MRI in the diagnosis of acute pancreatitis and the relationship between the T2* value and the severity of AP.
详细描述
- We design a prospective study about "Magetic Resonance Imaging Study of Acute Pancreatitis".
- We apply for an account and register our study on the clinicalTrials.
- In patients with acute pancreatitis, imaging is recommended to confirm the clinical diagnosis, investigate the etiology, and grade the severity of the disease . MR had the excellent resolution of soft tissue，and it has earned an ever more important role in the diagnosis of AP. With the continuous development of MR scanning techniques, the sequence of a multi-echo gradient recalled echo (GRE) T2*-weighted imaging (T2*WI), which acquires a spin echo signal, T2* relaxation acquires a gradient echo signal, is a relatively new MRI technique. The sequence of a GRE T2*WI requires high uniformity of the magnetic field, plus it can provide the T2* value, which can indirectly reflect changes in tissue biochemical components, thus it can be used for the early diagnosis quantitative diagnosis of some diseases .
- This calculation process for T2* value is completed using post-processing software on the workstation(Advantage workstation 4.4; GE Halthcare) directly after scanning.
- AP is a process of inflammation diffusion, in which cell edema will lead to hydrogen proton increase. In the inflammatory exudation process, T2* value will change. So we conduct our research. In this study, we will observe pancreas in the normal pancreas and AP, and discuss the relationship between T2* value and that of AP graded by the MR severity index (MRSI) and Acute Physiology And Chronic Healthy Evaluation II (APACHE II) scores.
- However, until now, there is no research on the sequence applied in the patients with AP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •acute onset of abdominal pain;
- •pancreatitis at first onset;
- •three-fold elevated amylase or lipase, excluding other causes of elevated enzymes; and
- •abdominal MR examination.
排除标准
- •inability to cooperate when MR imaging was performed;
- •a history of chronic pancreatitis;
- •AP due to pancreatic carcinoma;
- •hypoproteinemia;
- •with hypoproteinemia and other peritoneal/ retroperitoneal infection diseases ;
- •with iron deposition disorder (e.g. diabetes or blood system diseases).
结局指标
主要结局
The T2* Values in the Diagnosis of AP
时间窗: 1 year
Compare the difference of the T2\* value between the AP group and the control group.
次要结局
- The Relationship Between the T2* Value and the Severity of AP According to Apache II(1 year)
- The Difference of T2* Value Between the Edematous AP and Necrotizing AP(1 year)
- The T2* Value in Different Severity of AP According to MRSI(1 year)
研究者
研究点 (1)
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