Postoperative Analgesia After Cesarean Section; Comparison Among Ultrasound Guided Erector Spinae, Quadratus Lumborum or Transversus Abdominis Plane Blocks: A Prospective Randomized Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 140
- 试验地点
- 2
- 主要终点
- Postoperative morphine consumption
研究概览
简要总结
The aim of this prospective randomized controlled study is to compare the analgesic efficacy of the ultrasound-guided erector spinae plane block, ultrasound-guided quadratus lumborum plane block, and ultrasound-guided transversus abdominis plane block in patients undergoing elective cesarean section.
详细描述
Acute postpartum pain is a key determinant of maternal satisfaction; may lead to persistent postoperative pain.
Opioids are used to control severe pain. However, they have many common side effects as sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolerance, and respiratory depression.
Transversus abdominis plane (TAP) block is a regional injection of local anesthetic between the transversus abdominis and internal oblique muscle planes. TAP block affects the sensory nerves of the anterolateral abdominal wall (T6-L1) that innervate the abdomen. TAP block is an easy technique, and decreases postoperative pain and opioid consumption.
Erector Spinae Plane block (ESPB), first described for analgesia in thoracic neuropathic pain has also been reported for the management of other causes of acute postoperative pain.
Quadratus Lumborum block (QLB) differ from the transversus abdominis plane block (TAP) it is a block of the posterior abdominal wall. It is also referred to as an inter fascial plane block because it requires the injection of a local anesthetic into the thoracolumbar fascia (TLF).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •American Society of Anesthesiologists (ASA) classification II.
- •Female patients scheduled for elective cesarean section under spinal anesthesia.
排除标准
- •Patient refusal.
- •Patients who are taking analgesics for chronic illness or have history of substance abuse.
- •Patients who are unable to describe their postoperative pain (e.g., language barrier or neuropsychiatric disorder).
- •Patients with a history of coagulopathy.
- •Patients weight less than 60 kilograms.
- •Patient height less than 150 cm.
- •Patients with known local anesthetics and opioid allergy.
- •Patients with infection at the site of the needle puncture.
- •Patients with major respiratory, cardiac, renal, or hepatic disorders.
结局指标
主要结局
Postoperative morphine consumption
时间窗: 24 hours postoperatively
The rescue analgesia will be morphine IV bolus 3 mg with 5-minute lock out interval when Numeric Rating Scale (NRS)\>3, can be repeated till NRS˂3 guided with the occurrence of complication.
次要结局
- Degree of patient satisfaction(24 hours postoperatively)
- Time for first request of the rescue analgesia(24 hours postoperatively)
- Complications(24 hours postoperatively)
- Degree of pain(24 hours postoperatively)
研究者
Hasnaa Gamal Khafagy
Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Kafrelsheikh University, Egypt.
Kafrelsheikh University