NCT03259035已完成2 期
NEO: Neoadjuvant Chemotherapy, Excision and Observation for Early Rectal Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 19
- 主要终点
- Percentage of Organ Preservation
研究概览
简要总结
The purpose of this study is to find out the effects of chemotherapy followed by less invasive surgery on patients and their early rectal cancer. The approach of this trial will be considered a success if at least 65% of participants are able to keep the rectum.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed invasive well-moderately differentiated rectal adenocarcinoma diagnosed within 90 days prior to enrollment.
- •Tumour stage cT1-T3abN0 based on pelvic MRI
- •cT1N0- tumour invasion into submucosa, no radiographic evidence of mesorectal nodal metastasis, tumour deposits or vascular invasion.
- •cT2N0 - tumour invasion into muscularis propria, no radiographic evidence of mesorectal nodal metastasis, tumour deposits or vascular invasion.
- •cT3a,bN0- tumour invasion through the muscularis propria no more than 5 mm into the subserosa/perirectal tissue and clear of the circumferential radial margin (CRM). Absence of radiographic evidence of mesorectal nodal metastasis, tumour deposits or lymphovascular invasion.
- •Note: If the tumour is not visualized in the MRI but there is histological confirmation of rectal adenocarcinoma the patient is eligible.
- •cN0 stage based on pelvic MRI. Any nodes ≥ 10 mm in longest dimension are considered malignant, regardless of nodal morphology. For pelvic nodes < 10 mm in longest dimension, if nodes are seen and are deemed to be morphologically benign in the opinion of the radiologist and surgeon, the patient is eligible. Patients with visible pelvic sidewall nodes are excluded
- •M0 stage based on no evidence of metastatic disease by CT imaging.
- •Mid to low-lying tumour eligible for local tumour excision in the opinion of the treating surgeon.
- •Age of at least 18 years.
- •Medically fit to undergo radical surgery as per treating surgeon's discretion
- •No contraindications to protocol chemotherapy.
- •Adequate normal organ and marrow function as defined below (must be done within 30 days prior to enrolment):
- •ANC ≥ 1.5 x 109/L
- •platelet count ≥100 x 109/L
- •bilirubin < 1.5 ULN, excluding Gilbert's syndrome
- •Calculated creatinine clearance of ≥ 50 ml/min.
- •Clearance to be calculated using Cockcroft formula: Males: 1.23 x (140 - age) x weight (kg) - serum creatinine (μmol/l) ; Females: 1.05 x (140 - age) x weight (kg) - serum creatinine (μmol/l)
- •The patient must have an ECOG performance status of 0,
- •Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life and health utility questionnaires.
- •Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each patient must sign a consent form prior to enrollment in the trial to document their willingness to participate.
- •Must be accessible for treatment and follow up. Patients registered on this trial must be treated with chemotherapy and followed at the enrolling centre.
- •Protocol treatment is to begin within 5 working days of patient enrollment.
- •Women/men of childbearing potential must have agreed to use a highly effective contraceptive method during and for 6 months after completion of chemotherapy.
排除标准
- •Patient has pathologic high risk factors on either the initial biopsy specimen report or follow-up biopsy (if done): high histologic grade, mucinous histology, lymphatic or vascular invasion.
- •History of other malignancies, except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumours curatively treated with no evidence of disease for ≥ 5 years.
- •Synchronous cancer.
- •Prior treatment for rectal cancer.
- •Previous pelvic radiation for any reason.
- •Patients with known dihydropyrimidine dehydrogenase deficiency
- •Treatment with other investigational drugs or anti-cancer therapy within 28 days prior to enrolment.
- •Clinically significant (i.e. active) cardiovascular disease for example cerebro vascular accidents (< 6 months prior to enrolment), myocardial infarction (< 6 months prior to enrolment), unstable angina, New York Heart Association (NYHA) grade II or higher, congestive heart failure, serious cardiac arrhythmia requiring medication.
- •Any contra-indications to undergo MRI imaging.
研究组 & 干预措施
chemotherapy (FOLFOX or CAPOX) followed by tumour excision
Experimental
干预措施: Folfox Protocol (Drug)
chemotherapy (FOLFOX or CAPOX) followed by tumour excision
Experimental
干预措施: Capox (Drug)
结局指标
主要结局
Percentage of Organ Preservation
时间窗: 3 years
Defined as the percentage of patients with tumour downstaging to ypT0/T1good N0 and who avoid radical surgery.
次要结局
- Percentage of Locoregional Relapses at 3 Years(3 years)
- Percentage of Distant Relapse at 3 Years(3 years)
- Percentage of Disease Free at 3 Years(3 years)
- Rate of Intraoperative Complications(1 day)
研究者
研究点 (19)
Loading locations...
相似试验
已完成
不适用
Induction Chemotherapy, Chemoradiotherapy and Surgery in Locally Advanced Gastric Cancer PatientsAdenocarcinomaEffects of ChemotherapySurgeryGastrointestinal NeoplasmsGastric CancerNCT02454647Clinica Universidad de Navarra, Universidad de Navarra46
招募中
2 期
To evaluate Neoadjuvant chemotherapy in treatment of unresectable cervical cancer patientsIRCT20210808052110N1Shiraz University of Medical Sciences74
进行中（未招募）
3 期
Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or PlaceboTriple Negative Breast CancerNCT03281954NSABP Foundation Inc1,550
撤回
2 期
Study of neo adjuvant chemotherapy in large and/or lymphenode positive breast cancer (stage IIB-III pT2> 3cm). Multicentre - phase II - trial.NL-OMON30125Catharina-ziekenhuis50
招募中
3 期
Induction Chemotherapy Combined With Immunotherapy Followed by Concurrent Chemoradiation in Advanced Cervical CancerCervical CancerNCT05173272Sichuan Cancer Hospital and Research Institute286