NCT01042873Unknown4 期
The Hemodynamic Response to Prolonged Dobutamine Infusion
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Heart rate
研究概览
简要总结
A decrease in the response of beta 1 adrenergic receptors to agonists (desensitization) is thought to play a major role in the pathogenesis of diseases such as congestive heart failure. However, currently, there is no in vivo model that will enable us to measure desensitization of the hemodynamic responses to beta 1 adrenergic receptors in vivo.
Our hypothesis is that constant 3 hours intravenous infusion of the selective beta1 adrenergic receptor agonist dobutamine will result in gradual decline in hemodynamic responses to dobutamine over time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects
排除标准
- •consumption of any medications during the 2 weeks prior to the study
- •history of chest pain or tachycardia
研究组 & 干预措施
Intravenous dobutamine
Other
3 hours infusion of dobutamine
干预措施: 3 hours intravenous dobutamine (Drug)
结局指标
主要结局
Heart rate
时间窗: 3 hours
次要结局
- Systolic blood pressure(3 hours)
研究者
研究点 (1)
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