NCT04424706Unknown不适用
The Effect and Mechanism of MMP-9 in Inducing Atherosclerosis in Type 2 Diabetes
Majianhua1 个研究点 分布在 1 个国家目标入组 180 人开始时间: 2020年6月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- total MMP-9 levels
研究概览
简要总结
The study will assess the serum expression of MMP-9 in normal people, type 2 diabetic patients and type 2 diabetic patients with atherosclerosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •volunteer to participate and be able to sign informed consent prior to the trial.
- •patients with type 2 diabetes, aged 18-60 years old, meeting WHO1999 diagnostic criteria, have not used any drugs.
- •The patients have completed carotid ultrasound during hospitalization.
排除标准
- •patients with any antidiabetic drugs.
- •impaired liver and kidney function with ALT 2.5 times higher than the upper limit of normal value; Serum creatinine was 1.3 times higher than the upper limit of normal.
- •drug abuse and alcohol dependence in the past 5 years.
- •systemic hormone therapy was used in the last three months.
- •patients with infection and stress within 4 weeks.
- •any other obvious conditions or associated diseases determined by the researcher: such as severe cardiopulmonary diseases, endocrine diseases, neurological diseases, tumors and other diseases, other pancreatic diseases, history of mental diseases.
结局指标
主要结局
total MMP-9 levels
时间窗: 6 months
the different group of total MMP-9 levels
次要结局
未报告次要终点
研究者
Majianhua
Head of Department of Endocrinology
Nanjing First Hospital, Nanjing Medical University
研究点 (1)
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