ISRCTN10924200已完成未知
Effects of Bifidobacterium on skin wrinkle, hydration, transepidermal water loss, elasticity and gloss: a randomized, double-blind, placebo-controlled, and parallel clinical trial
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 170
研究概览
简要总结
2022 Results article in https://doi.org/10.3390/dermato2020005 (added 17/08/2022)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Korean female subjects aged between 30 and 60
- •2. Dry skin on their cheek (hydration value is below 48 A.U. by Corneometer®)
- •3. Skin wrinkles over grade 3 by DERMAPRO standard photograph
- •4. No chronic or acute disease including skin disease
- •5. Signed informed consent
- •6. Cooperative and available for follow-up during the study period
排除标准
- •1. Consumed probiotics as dietary supplements, food or beverage products during the last 2 weeks
- •2. Pregnant, nursing or planning to become pregnant
- •3. Irritation or symptomatic allergy for food including ingredients of cosmetic, medical and test product.
- •4. Took oral or topical antibiotics during the previous 3 months
- •5. Took oral retinoid/steroid drug or topical application included steroid during previous 6 months
- •6. Use functional cosmetics for improvement of skin wrinkle, hydration and elasticity within 3 months
- •7. Have an experience on the test site (skin decortications, botox and other skin treatment)
- •8. Participated in a previous study without an appropriate intervening period (3 months) between studies
- •9. Have a disease which affects the study (e.g. cardiovascular, kidney, liver, thyroid, gastrointestinal disease, gout)
- •10. Any skin disease (e.g. atopic dermatitis) at the test site
- •11. Any chronic disease (e.g. diabetes, asthma, high blood pressure) or psychiatric disorder (e.g. depression, schizophrenia, alcoholism, drug addiction)
- •12. Take a medicine for the treatment of obesity (e.g. antidepressants, anorectics), contraceptives, hormones or diuretics
- •13. Drink excessive alcohol (over 30 g alcohol per day)
- •14. Sensitive or hypersensitive skin
- •15. Damaged skin in or around the test area which includes sunburn, tattoos, scars or other disfiguration on the test area
- •16. Abnormal result in screening clinical chemical analysis by medical specialist
- •17. Problem which may interfere with the aim of the study as judged by the principal investigator
研究者
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