Effects of body composition on clinical, immunological, and microbiological outcomes following non-surgical periodontal therapy in patients with chronic periodontitis: a cohort study

Joint UCLH/UCL Biomedical Research Unit0 个研究点目标入组 115 人开始时间: 2018年6月12日最近更新: 2022年3月14日

适应症

试验速览

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/31994205/ (added 04/03/2022)

•1. Individuals at least 35 years of age and in good general health
•2. Have BMI between 20-24.9 (WHO Normal) or BMI =30 (WHO Obese)
•3. Participants must have a minimum of 15 natural teeth
•4. Participants must have severe periodontal disease defined as >30% sites with PPD =5 attachment loss (1998 AAP classification)
•5. Participants must voluntarily agree to sign the consent form

•1. BMI between 25-29.9 (WHO overweight)
•2. Current smokers or former smokers who have smoked within the previous 5 years
•3. History of diabetes
•4. Uncontrolled or currently undergoing treatment for serious systemic medical conditions including hepatic disease, renal disease, transmittable diseases, cancer, or HIV
•5. On chronic treatment (defined as 2 weeks or more) of antibiotic, anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam
•6. History of alcohol or drug abuse
•7. Self reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing which can affect interpretation of study results)
•8. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study
•9. Participation in any other dental study concurrently

发起方

Joint UCLH/UCL Biomedical Research Unit