NCT00147563已完成4 期
A Double-Blind, Parallel Design Study to Compare the Effectiveness of Eplerenone Versus Atenolol in Reversing the Remodeling of Resistance Arteries in Subjects With Mild to Moderate Primary Hypertension
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- Pfizer
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- The change from baseline to week 52 in the media/lumen ratio and the maximum % relaxation response to acetylcholine of gluteal subcutaneous resistance vessels, measured from the gluteal biopsy.
研究概览
简要总结
To investigate the impact of antihypertensive therapy with the selective mineralocorticoid receptor blocker, eplerenone, on small resistance artery remodeling, compared to the effect of equivalent blood pressure control achieved with a b-blocker, atenolol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pt with essential hypertension who have never been treated or untreated within the previous 6 months
排除标准
- •History of Malignant Hypertension
- •Sitting diastolic blood pressure > 115mmHg or sitting Systolic blood pressure > 200mmHg
结局指标
主要结局
The change from baseline to week 52 in the media/lumen ratio and the maximum % relaxation response to acetylcholine of gluteal subcutaneous resistance vessels, measured from the gluteal biopsy.
次要结局
- Will be done for both the Intent to Treat and per protocol populations, and use both the LOCF and OC methods
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Antihypertensive Effect of Fermented Milk With Lactococcus Lactis on Prehypertensive SubjectsHypertensionNCT02670811Centro de Investigación en Alimentación y Desarrollo A.C.36
已完成
4 期
Mineralocorticoid Receptor Antagonists in Type 2 DiabetesDiabetes Type 2NCT02809963Herlev Hospital140
已完成
2 期
Evaluating Alternative Medical Therapies in Primary HyperparathyroidismPrimary HyperparathyroidismNCT02525796Brigham and Women's Hospital69
已完成
4 期
An Investigation Into The Anti-hypertensive And Potential Anti-inflammatory Actions Of DapagliflozinType 2 DiabetesNCT02433678University at Buffalo52
已完成
2 期
An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.Resistant HypertensionNCT05562934Novartis Pharmaceuticals189