Reducing Hippocampal Hyperactivity in Patients With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Hippocampal activity during the pattern separation task
研究概览
简要总结
This study aims to reduce hippocampal activity in people at high risk of developing Alzheimer's disease (AD) and aims to examine whether this improves their episodic memory performance. We apply mental strategy trainings with strategies extracted from our previous study that applied real-time fMRI neurofeedback to reduce hippocampal activity. Participants take part in mental strategy trainings 2, 4, or 6 times. At baseline and after each 2 trainings, we assess their hippocampal activity as well as their episodic memory performance using an fMRI pattern separation task. In addition, we will gather blood samples to obtain Apolipoprotein E gene status (ApoE, only once) as well as plasma pTau (pTau217; 4 time-points). ApoE will be included as a covariate in our statistical models. For pTau217, we will calculate the change between each assessment to examine whether the mental strategy training will change the accumulation of pTau217.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosis of Mild Cognitive Impairment
- •between 60 - 80 years of age
- •fluent in German
- •normal or corrected-to-normal vision
- •normal or corrected-to-normal hearing
排除标准
- •any history of seizures
- •current psychotropic medication
- •other severe neurological or psychiatric disease
- •current or lifetime drug or alcohol abuse
- •severe brain damage other than atrophy in the hippocampus or the medial temporal lobe
- •claustrophobia
- •magnetisable implants (e.g., cardiac pacemakers, brain stimulator)
结局指标
主要结局
Hippocampal activity during the pattern separation task
时间窗: We assess hippocampal activity 4 times from baseline until the last assessment (approximately 10 weeks later).
In each 4 fMRI sessions, we apply a pattern separation task (i.e., the mnemonic similarity test, MST). Participants need to answer to specific trial types. These are stimuli of everyday objects and the participants have to identify if a stimulus is "new" (they have not seen it before), "old" (exactly the same stimulus has been presented already) or "similar" (a stimulus has been shown before but was different in shape or colour). During each task, we will evaluate their hippocampal activity using similar "lure" trials that rely on pattern separation.
次要结局
- Pattern completion errors(We will assess pattern completion errors 4 times from baseline until the last assessment (approximately 10 weeks later).)
- Pattern Separation success(We will asssess pattern separation success 4 times from baseline until the last assessment (approximately 10 weeks later).)
- Lure Discrimination Index(We will evaluate the LDI 4 times from baseline until the last assessment (approximately 10 weeks later).)
研究者
Jessica Peter
Prof. Dr. Jessica Peter
University of Bern