The Effect of Pregabalin on Post-operative Pain and Opioid Consumption in Spine Surgery, a Prospective, Randomized, Controlled Study
试验速览
- 阶段
- 2 期
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Morphia dose
研究概览
简要总结
The effect of pregabalin on post-operative pain and opioid consumption in spine surgery, a prospective, randomized, controlled study
详细描述
Aim of the work:
The aim of our study is to compare the analgesic effect of pre-emptive oral pregabalin 150mg on acute postoperative pain and opioid consumption in spine surgery. Evaluated by visual analog scale (VAS)
primary outcome measure is the total amount of rescue morphine received by patients for 24h postoperatively.
secondary outcome measures include level of acute postoperative pain by VAS, and duration of hospital stay
Patients and methods :
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Care Provider)
盲法说明
care provider
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •: This prospective randomized clinical study will include eighty patients with ASA I-II, aged 18-60 years scheduled for spine surgery
排除标准
- •: Excluded from the study are patients with known allergy to the study drugs, significant cardiac, respiratory, renal, CNS or hepatic disease, drug or alcohol abuse, pregnant women, patients refusing participation and psychiatric or mental illness that would interfere with perception and assessment of pain.
研究组 & 干预措施
Study group
patients have spine surgery receive oral pregabalin 150 mg 1 hour before surgery
干预措施: Pregabalin 150mg (Drug)
Placebo group
patients will receive placebo 1 hour before surgery with a sip of water.
干预措施: Placebo (Other)
结局指标
主要结局
Morphia dose
时间窗: 24 hour postoperative
the total amount of rescue morphine received by patients for 24h postoperatively.
次要结局
- Postoperative pain(24 hour postoperative)
研究者
Mohamed galal aly
Professor of anesthesia and intensive care
Assiut University