Does Short Term Discontinuation of Self-performed Oral Hygiene Procedures Influence the Composition of the Salivary Microbiota?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Comparison of changes in α-diversity in saliva samples before and after discontinuation of regular oral care
研究概览
简要总结
The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to discontinuation of oral hygiene.
详细描述
35 orally healthy individuals will be enrolled in this study, in which they will discontinue regular oral hygiene procedures for a period of 10 days. Clinical registrations and collection of microbiological samples (supragingival and saliva) will be performed at baseline and 4, 7 and 10 days after discontinuation of regular oral hygiene, and will be repeated 14 days after regular oral hygiene has been resumed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Oral and systemically healthy individuals
排除标准
- •Periodontitis
- •Dental caries
- •Systemic diseases or medications with known associations to oral health
- •Antibiotics within the latest 6 month
结局指标
主要结局
Comparison of changes in α-diversity in saliva samples before and after discontinuation of regular oral care
时间窗: 10 days of discontinuation of regular oral care and 14 days after resuming regular oral care
Comparison of α-diversity in saliva samples before and after discontinuation of regular oral hygiene
次要结局
- Comparison of species specific changes in saliva samples before and after discontinuation of regular oral care(10 days of discontinuation of regular oral care and 14 days after resuming regular oral care)
研究者
Daniel Belstrøm, DDS, PhD
Assistant professor
University of Copenhagen