Short and Long Term Alterations of Subgingival and Salivary Microbiota in Relation to Periodontal Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Changes in α-diversity in saliva samples collected .
研究概览
简要总结
The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.
详细描述
In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Manifest chronic periodontitis according to international classification
排除标准
- •Other treatment requiring oral conditions
- •Systemic antibiotics within the latest 6 months
- •Systemic diseases and medications with known associations to periodontitis
- •Pregnancy and breastfeeding
结局指标
主要结局
Changes in α-diversity in saliva samples collected .
时间窗: Baseline and 12 weeks
Comparison of α-diversity in saliva samples collected before periodontal treatment and 12 weeks after treatment
次要结局
- Specis specific changes in saliva samples collected(Baseline and 12 weeks)
研究者
Daniel Belstrøm, DDS, PhD
Assistant professor
University of Copenhagen