NCT02885064
Completed
Not Applicable
Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dental Caries
- Sponsor
- University of North Carolina, Chapel Hill
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Change from Baseline to Month 6 in Clusters Of Orthologous Groups of proteins
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study is observational only and is intended to evaluate changes in the makeup and function of bacteria naturally present in the mouth during treatment with braces to straighten teeth.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA I or II (ASA I is a healthy patient, ASA II is patient with minor systemic disease)
- •Patient must be receiving orthodontic treatment at the University of North Carolina School of Dentistry and not yet be in active treatment
Exclusion Criteria
- •Patients who have used antibacterial therapy in the past 3 months
- •Patients who report current smoking
- •ASA III or above (Patients with severe systemic diseases)
Outcomes
Primary Outcomes
Change from Baseline to Month 6 in Clusters Of Orthologous Groups of proteins
Time Frame: Baseline, Month 6
Change in Shannon diversity index from Baseline to Month 6
Time Frame: Baseline, Month 6
Secondary Outcomes
- Change in gingival index(Baseline, Month 6)
- Change in decalcification index(Baseline, Month 6)
Study Sites (1)
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