Does Meal Texture Have Different Impact on Glucose Metabolism and Intestinal Hormone Response After Gastric Bypass and Sleeve Gastrectomy Operated Patients?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- GLP-1 response
研究概览
简要总结
The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 18 years
- •RYGB or SG operation > 12 months prior to inclusion
- •Weight stable (± 3 kg during the last month)
- •HbA1c < 48 mmol/mol before surgery, and no history of diabetes
- •HbA1c < 48 mmol/mol and fasting plasma glucose < 6.1 mmol/l at inclusion
排除标准
- •Thyrotoxicosis or inadequately treated hypothyreosis
- •Hemoglobin < 6.5 mmol/l at inclusion
- •Pregnancy or breast feeding
- •Medication affecting the planned examinations
研究组 & 干预措施
Gastric bypass operated patients
Two test days in a randomized, patient-blinded, cross-over design
干预措施: Liquid meal (Other)
Gastric bypass operated patients
Two test days in a randomized, patient-blinded, cross-over design
干预措施: Solid meal (Other)
Gastric sleeve operated patients
Two test days in a randomized, patient-blinded, cross-over design
干预措施: Liquid meal (Other)
Gastric sleeve operated patients
Two test days in a randomized, patient-blinded, cross-over design
干预措施: Solid meal (Other)
Control arm
Two test days in a randomized, patient-blinded, cross-over design
干预措施: Liquid meal (Other)
Control arm
Two test days in a randomized, patient-blinded, cross-over design
干预措施: Solid meal (Other)
结局指标
主要结局
GLP-1 response
时间窗: 240 minutes
GLP-1 response after a liquid meal test compared to a solid meal test
次要结局
- Difference in gut hormone response after bariatric surgery(240 minutes)
研究者
Nora Elisabeth Hedbäck
MD, principal inverstigator
Hvidovre University Hospital