Food Modification to Alter Glycaemia and Insulinaemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Insulin
研究概览
简要总结
The study specifically aims to determine glycemic and insulinemic response of added low GI ingredients, beta-glucan, resistant starch and isomaltulose to foods.
详细描述
There will be a total of 9 test sessions and each session will last up to 3 hours. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations. Subject will be served the test food and to consume within15 minutes. Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy Males
- •Chinese ethnicity
- •Age ≥21 and ≤ 40 years
- •Body mass index between 18.5 to 25 kg/m2
- •Normal blood pressure ≤140/90 mmHg
- •Fasting blood glucose <6.0 mmol/L
- •In general good health
排除标准
- •Current smoker
- •Have metabolic diseases (such as diabetes, hypertension etc)
- •Have glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
- •Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
- •Have an ongoing infection or currently undergoing treatment at the time of screening
- •Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- •Have active Tuberculosis (TB) or currently receiving treatment for TB
- •Intolerances or allergies to any foods
- •Partake in sports at the competitive and/or endurance levels
- •Intentionally restrict food intake
研究组 & 干预措施
Glucose Reference 1
50g glucose dissolve in 250 ml of water
干预措施: Glucose Reference 1 (Other)
Glucose Reference 2
50g glucose dissolve in 250 ml of water
干预措施: Glucose Reference 2 (Other)
Glucose Reference 3
50g glucose dissolve in 250 ml of water
干预措施: Glucose Reference 3 (Other)
Wheat Yellow Noodle
Boiled 170.6g of wheat yellow noodle
干预措施: Wheat Yellow Noodle (Other)
Beta-glucan Yellow Noodle
Boiled 230.4g of beta-glucan yellow noodle.
干预措施: Beta-glucan yellow Noodle (Other)
Rice Roll
Steamed 197.6g of rice roll
干预措施: Rice Roll (Other)
Rice Roll with resistant starch
Steamed 232.6g of rice roll fortified with resistant starch
干预措施: Rice Roll with resistant starch (Other)
Sucrose jelly
Jelly made with 25g of sucrose and 48g of wheat white bread
干预措施: Sucrose Jelly (Other)
Isomaltulose jelly
Jelly made with 25g of isomaltulose and 48g of wheat white bread
干预措施: Isomaltulose Jelly (Other)
结局指标
主要结局
Insulin
时间窗: up to 180 minutes
Blood glucose will be collected using finger prick method and analysed using Cobas analyser
Glucose
时间窗: up to 180 minutes
Blood glucose will be collected using finger prick method and analysed using Hemocue analyser
次要结局
未报告次要终点
研究者
JeyaKumar Henry
Principal Investigator
Clinical Nutrition Research Centre, Singapore