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临床试验/NCT03706378
NCT03706378已完成不适用

Food Modification to Alter Glycaemia and Insulinaemia

Clinical Nutrition Research Centre, Singapore2 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2017年8月18日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
14
试验地点
2
主要终点
Insulin

研究概览

简要总结

The study specifically aims to determine glycemic and insulinemic response of added low GI ingredients, beta-glucan, resistant starch and isomaltulose to foods.

详细描述

There will be a total of 9 test sessions and each session will last up to 3 hours. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations. Subject will be served the test food and to consume within15 minutes. Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Other
盲法
None

入排标准

年龄范围
21 Years 至 40 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Healthy Males
  • Chinese ethnicity
  • Age ≥21 and ≤ 40 years
  • Body mass index between 18.5 to 25 kg/m2
  • Normal blood pressure ≤140/90 mmHg
  • Fasting blood glucose <6.0 mmol/L
  • In general good health

排除标准

  • Current smoker
  • Have metabolic diseases (such as diabetes, hypertension etc)
  • Have glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
  • Have an ongoing infection or currently undergoing treatment at the time of screening
  • Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
  • Have active Tuberculosis (TB) or currently receiving treatment for TB
  • Intolerances or allergies to any foods
  • Partake in sports at the competitive and/or endurance levels
  • Intentionally restrict food intake

研究组 & 干预措施

Glucose Reference 1

Other

50g glucose dissolve in 250 ml of water

干预措施: Glucose Reference 1 (Other)

Glucose Reference 2

Other

50g glucose dissolve in 250 ml of water

干预措施: Glucose Reference 2 (Other)

Glucose Reference 3

Other

50g glucose dissolve in 250 ml of water

干预措施: Glucose Reference 3 (Other)

Wheat Yellow Noodle

Experimental

Boiled 170.6g of wheat yellow noodle

干预措施: Wheat Yellow Noodle (Other)

Beta-glucan Yellow Noodle

Experimental

Boiled 230.4g of beta-glucan yellow noodle.

干预措施: Beta-glucan yellow Noodle (Other)

Rice Roll

Experimental

Steamed 197.6g of rice roll

干预措施: Rice Roll (Other)

Rice Roll with resistant starch

Experimental

Steamed 232.6g of rice roll fortified with resistant starch

干预措施: Rice Roll with resistant starch (Other)

Sucrose jelly

Experimental

Jelly made with 25g of sucrose and 48g of wheat white bread

干预措施: Sucrose Jelly (Other)

Isomaltulose jelly

Experimental

Jelly made with 25g of isomaltulose and 48g of wheat white bread

干预措施: Isomaltulose Jelly (Other)

结局指标

主要结局

Insulin

时间窗: up to 180 minutes

Blood glucose will be collected using finger prick method and analysed using Cobas analyser

Glucose

时间窗: up to 180 minutes

Blood glucose will be collected using finger prick method and analysed using Hemocue analyser

次要结局

未报告次要终点

研究者

发起方
Clinical Nutrition Research Centre, Singapore
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

JeyaKumar Henry

Principal Investigator

Clinical Nutrition Research Centre, Singapore

研究点 (2)

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