NL-OMON42302已完成2 期
Pharmacokinetics of two high dose regimes of intravenous vitamin C in critically ill patients - Pharmacokinetics of intravenous vitamin C in critically ill patient
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Sepsis or SIRS (systemic inflammatory response syndrome), after major surgery or trauma
- •Non-neurological sequential organ failure score (SOFA) >6
- •Expected length of ICU stay >96 hours
- •Informed consent initially the legal representative and later by the patient
排除标准
- •Admission after out of hospital cardiac arrest
- •Prior use of supplemental vitamin C in the week before
- •Major bleeding
- •Pre-existent renal insufficiency defined as an eGFR < 30 ml/min/1.73 m2 (stadium 4-5)
- •Expected need for renal replacement therapy within 48 hours
- •Known glucose 6-phosphate dehydrogenase deficiency
- •History of urolithiasis or oxalate nephropathy
- •Previous use of prolonged high dose vitamin C supplements
- •Hemochromatosis
研究者
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