NCT05812079尚未招募不适用
Assessing the Protective Role of Insulin Like Growth Factor 1 Against Oxidative Stress in Vitiligo Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 33
- 主要终点
- Investigate for IGF-1 and IMA levels in vitiligo
研究概览
简要总结
Insulin like growth factor has a protective role on melanocytes against the oxidative stress. The aim is to investigate this effect in vitiligo patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-segmental vitiligo
排除标准
- •Pregnant or lactating females
- •Patients with any endocrinal disease known to affect GH or IGF-1 as Diabetes (by measuring HbA1c) and Thyroid disturbance (by measuring TSH)
- •Patients with liver disease (by measuring AST, ALT and GGT)
- •Obese patients (by measuring BMI)
- •Patients with history of ischemic heart disease (known medical history of angina or myocardial infarction or history of recurrent chest pain, left shoulder pain, shortness of breath or fatigue on the ordinary effort or less than the ordinary effort )
- •Patients with history of Peripheral arterial disease (Known medical history of peripheral arterial thrombosis or history of recurrent claudications)
- •Patients with history of cerebero-vascular disease (known medical history of transient ischemic attacks or stroke)
- •Patients who received systemic treatment for vitiligo during the previous six months or topical treatment during the previous two months
结局指标
主要结局
Investigate for IGF-1 and IMA levels in vitiligo
时间窗: one year
To measure the level of IGF-1 and the level of IMA in perilesional and distant skin of vitiligo patients and compare these levels with normal controls to investigate the relationship between IGF-1, as a protective from oxidative stress and IMA, as a marker of oxidative stress in vitiligo.
次要结局
- Measure IMA in vitiligo and correlate it with psychological status of patients(One year)
研究者
Marwa Salah El-Din El-Mesidy
Associate Professor
Cairo University
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