Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Renal arterial resistive index (RI).
研究概览
简要总结
To investigate the influence of PEEP (Positive end-expiratory pressure), changes in preload (patient position) and changes in afterload (phenylephrine) on ultrasound measures of renal perfusion in patients after uncomplicated cardiac surgery.
To investigate the effects of phenylephrine on both invasive measures of the systemic- and pulmonary circulation and, secondarily, to assess the induced changes in echocardiographic indices of left- and right ventricular systolic- and diastolic function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
盲法说明
Ultrasound analysis is performed offline and details on participants and time of measurement are blinded for the person doing the analysis. The personnel responsible for obtaining data will not be blinded towards any of the interventions.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients ≥ 18 years scheduled for open elective cardiac surgery at the Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital.
排除标准
- •Insufficient ultrasonographic imaging of the kidneys
- •Known morphological kidney disease
- •Preoperative dialysis
- •Chronic atrial fibrillation
- •Planned mitral valve surgery
研究组 & 干预措施
All patients included
干预措施: Phenylephrine (Drug)
All patients included
干预措施: Combination of PEEP and positioning (Other)
结局指标
主要结局
Renal arterial resistive index (RI).
时间窗: 75 minutes
The ratio SVR/PVR (systemic vascular resistance/pulmonary vascular resistance)
时间窗: 75 minutes
次要结局
- Transoesophageal measurement of left and right ventricular function 5(75 minutes)
- Renal venous impedance index.(75 minutes)
- Transoesophageal measurement of left and right ventricular function 1(75 minutes)
- Transoesophageal measurement of left and right ventricular function 6(75 minutes)
- Renal venous stasis index.(75 minutes)
- Portal vein pulsatility fraction.(75 minutes)
- Cardiac output(75 minutes)
- Arterial blood pressure, central venous pressure, pulmonary blood pressure, pulmonary capillary wedge pressure.(75 minutes)
- Transoesophageal measurement of left and right ventricular function 2(75 minutes)
- Transoesophageal measurement of left and right ventricular function 3(75 minutes)
- Transoesophageal measurement of left and right ventricular function 4(75 minutes)
研究者
Johan Fridolf Hermansen
Principal Investigator
Aarhus University Hospital