Lymph Node Metastasis and Tumor Deposit in the Short Gastric Mesentery Following Total Gastrectomy With D2 Lymphadenectomy Plus Complete Mesogastric Excision for Gastric Cancer: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Rate of lymph node metastasis and tumor deposit in the short gastric mesentery
研究概览
简要总结
This study aims to explore lymph node metastasis in the short gastric mesentery following total gastrectomy with D2 lymphadenectomy plus complete mesogastric excision, providing evidence-based medicine for standardizing lymph node dissection in gastric cancer.
详细描述
According to the 6th edition of the Japanese Gastric Cancer Treatment Guidelines; total gastrectomy with D2 lymphadenectomy includes groups No.1 to No.7, No.8a, No.9, No.11p, No.11d, and No.12a. The No.4sa group lymph nodes are defined as the lymph nodes along the short gastric vessel, No.10 group lymph nodes are defined as the lymph nodes at the splenic hilum including the lymph nodes at the roots of the short gastric arteries. In routine total gastrectomy with D2 combined with CME surgery, the standard practice involves resection of the short gastric mesentery (No.4sa group and No. 10 group). There are typically 3-4 short gastric arteries in the human body, further investigation is required to determine the lymph node metastasis rates in each short gastric mesentery. Patients undergoing total gastrectomy with D2 combined with CME will have their short gastric mesenteries anatomically separated for examination, and this aims to analyze the positive rate of lymph nodes in the short gastric mesentery and investigate the correlation between tumor location, staging, and lymph node metastasis in the short gastric mesentery.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged older than 18 years and younger than 85 years
- •Primary gastric adenocarcinoma confirmed by preoperative pathology result
- •cT2-4aN0-3M0 at preoperative evaluation according to the American Joint 8 Committee on Cancer (AJCC) Cancer Staging Manual 8th Edition
- •Patients who received total gastrectomy with D2 lymphadenectomy plus complete mesogastric excision
- •American Society of Anesthesiologists (ASA) class I, II, or III
- •Written informed consent
排除标准
- •Negative preoperative biopsy
- •Too late tumour stage or metastasis (cT4b/M1)
- •BMI>30 kg/m2
- •previous neoadjuvant chemotherapy or radiotherapy
- •Previous upper abdominal surgery
- •Combined with other malignant diseases
- •Reject operation
结局指标
主要结局
Rate of lymph node metastasis and tumor deposit in the short gastric mesentery
时间窗: through study completion, an average of 1 year
次要结局
未报告次要终点
研究者
Jichao Qin
Professor
First Affiliated Hospital of Zhejiang University
