Do Dietary Patterns Influence Your Weight Management and Circadian Rhythms?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Circadian phase of melatonin rhythm
研究概览
简要总结
The goal of this clinical trial is to test the effects of dietary composition on the rhythms of food intake, appetite regulation, and rhythms of energy expenditure.
Participants will:
complete 2 field-based dietary interventions be provided with standard meals record daily food intake in a real-time manner complete 2 inpatient stays be provided with standard meals have frequent blood draws provide urine, saliva, and stool samples
详细描述
Obesity is an ongoing epidemic and a serious public health problem. Recent insights into the involvement of the circadian system (i.e., an internal biological rhythm) in energy expenditure and appetite control offer a new perspective to understand the relationship between dietary composition and weight management. Particularly, dietary composition may impact whole-body physiology in part through changes in the circadian system. The study protocol is designed to test the effects of dietary composition, on the rhythms of food intake and appetite regulation, and rhythms of energy expenditure. This study seeks to understand the relationship between dietary composition and weight control in order to lay the groundwork for evidence-based dietary intervention to combat obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-45 yr old
- •BMI 18.5-29.9
- •No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
- •Without medication use (except oral contraceptives)
排除标准
- •Currently smoking/vaping or 5 or more years of smoking/vaping
- •History of drug or alcohol dependency
- •History of psychiatric illness or disorder
- •People with food allergies/intolerances or following specific diets
结局指标
主要结局
Circadian phase of melatonin rhythm
时间窗: Days 18-19
Hourly plasma melatonin will be measured under the Constant Routine condition
Percentage of daily caloric intake in the biological evening
时间窗: Days 8-14
Percentage of caloric intake within the 4 hours before bedtime will be derived from real-time record of food and beverage intake during the intervention period
次要结局
- Circadian amplitude of melatonin rhythm(Days 18-19)
- Circadian amplitude of subjective hunger rhythms(Days 18-19)
- Circadian phase of resting energy expenditure(Days 18-19)
研究者
Frank AJL Scheer, PhD
Professor
Brigham and Women's Hospital