NCT03368989已完成不适用
The Effects of Radium-223 Dichloride Therapy on Radionuclide Bone Scan Lesions.
The University of Texas Health Science Center, Houston1 个研究点 分布在 1 个国家目标入组 21 人开始时间: 2014年2月11日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Change in number of osteoblastic bone lesions
研究概览
简要总结
To describe the changes seen on bone scan and correlate them with changes in relative chemical biomarkers, patient's functional status and level of pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Prostate cancer patients scheduled for treatment with Radium-223.
排除标准
- •Patients not completing their treatment regimen for any reason
研究组 & 干预措施
treatment with radium-223 Dichloride (Xofigo)
干预措施: Radium-223 dichloride (Drug)
结局指标
主要结局
Change in number of osteoblastic bone lesions
时间窗: Pretreatment (about 30 days before treatment) and post treatment (about 4 weeks after treatment)
number of lesions specified before and after the treatment with a bone scan
次要结局
- Hemoglobin level(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
- functional status as indicated by score on the Eastern Cooperative Oncology Group (ECOG) performance scale(Pretreatment (about 1 to 3 days before each treatment) for a total of 6 treatments)
- (ALP) alkaline phosphatase level(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
- pain level as assessed by numeric rating score(Pretreatment (about 1 to 3 days before each treatment) for a total of 6 treatments)
- Platelet level(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
- (PSA) prostate specific antigen level(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
- Neutrophil count(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
- Creatinine level(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
- white blood cell count(pretreatment (about 1 to 7 days before each treatment) for a total of 6 treatments)
研究者
Isis W Gayed
Professor
The University of Texas Health Science Center, Houston
研究点 (1)
Loading locations...
相似试验
已完成
1 期
Pharmacodynamic Study of Radium-223 in Men With Bone Metastatic Castration-Resistant Prostate CancerBone Metastatic Castration-Resistant Prostate CancerNCT02204943Duke University20
已完成
2 期
Standard Dose Versus High Dose and Versus Extended Standard Dose Radium-223 Dichloride in Castration-resistant Prostate Cancer Metastatic to the BoneProstatic NeoplasmsNCT02023697Bayer391
招募中
不适用
Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate CancerStage IVB Prostate Cancer AJCC v8Metastatic Malignant Neoplasm in the BoneCastration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaNCT04489719University of Washington48
已完成
不适用
Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)Complex Regional Pain Syndrome Type I of the Upper LimbUnilateral Limb Pain of Other OriginHealthy SubjectsNCT01623141Ruhr University of Bochum53
招募中
4 期
Role of Strontium Ranelate in Proximal Femur Fragility Fractures.Fragility FractureClinical TrialFracture, Pertrochanteric FemurNCT05712616Aga Khan University Hospital, Pakistan100