The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Number of cases developed acute kidney injury
研究概览
简要总结
This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.
详细描述
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication following cardiac surgery occurring in 15-30% of patients. It is associated with increased morbidity and mortality as well as prolonged hospital stay and higher medical costs.
The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.
Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 21 years.
- •Both sexes.
- •Undergoing elective on-pump cardiac surgery.
排除标准
- •Patients with chronic kidney disease.
- •Patients with any renal pathology or anatomic kidney abnormalities.
- •Patients on renal replacement therapy.
结局指标
主要结局
Number of cases developed acute kidney injury
时间窗: 7 days after the procedure
Number of cases developed acute kidney injury as defined by KIDGO guidelines (serum creatinine ≥ 0.3 mg/dL from base line within 48 hours, or ≥1.5 fold within 7 days, or urine output \<0.5 mL/kg/hour for six hours) in patients undergoing open heart surgery.
次要结局
- Length of intensive care unit stay(7 days after the procedure)
- Length of hospital stay(7 days after the procedure)
- Need for renal replacement therapy(7 days after the procedure)
- Number of patients developed chronic kidney disease(7 days after the procedure)
- Mortality rate(7 days after the procedure)
研究者
Amany Mohamed Badr Ali Badr
Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
Tanta University