Tomography Positron Emission Assessment of the Impact of Cardiac Rehabilitation on Coronary Endothelial Function in Cardiac Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Rate of myocardial blood flow during the cold test
研究概览
简要总结
In patients with heart failure, the drive to the effort has demonstrated its safety and its interest. Patients with heart failure, endothelium-dependent peripheral vasodilatation is impaired by decreased activity of endothelial NO synthase. The rehabilitation training significantly improves peripheral endothelial function, and this improvement is correlated to the increase in exercise capacity. The impact on coronary endothelial function remains poorly documented, especially in non-ischemic dilated heart disease.
The main objective of this study is to investigate the effectiveness of cardiac rehabilitation on the restoration of coronary endothelial function in cardiac failure patient evaluated with Tomography Positron Emission 15O-H2O.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with heart failure with nonischemic dilated cardiomyopathy
- •Class II-III NYHA (New York Heart Association)
- •Having no contra-indication to the effort
- •Fraction Ejection ≤ 40%
- •patient who will have cardiac rehabilitation
- •Age over 18 years
- •informed consent signed
- •patient with a social security scheme
排除标准
- •Hypertension> 160/90 mmHg
- •High cholesterol level > 6.0 mmol / l
- •Diabetes known and treated
- •Active smoking
- •Valvular heart disease, congenital or ischemic
- •Pregnant or breastfeeding women
- •Age <18 years
- •Major Adult guardianship
结局指标
主要结局
Rate of myocardial blood flow during the cold test
时间窗: change over baseline and after 3 month
次要结局
未报告次要终点