Executive Control, Processing Speed and Memory Function in Long- Term Peripheral Neuropathic Pain and Fibromyalgia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 2
- 主要终点
- Objective neuropsychological tests
研究概览
简要总结
The goal of this project is to investigate and improve executive control function in two distinct pain conditions, namely neuropathic pain and fibromyalgia (FM). It is hypothesized that there is a significant difference in the executive control function of patients with neuropathic pain and FM pain. It is also hypothesized that all participants with poor executive control functioning will report significant improvements in pain intensity, functioning and cognitive complaints following cognitive training. The study tests and influence the working memory concepts of inhibition, updating and flexibility through an experimental, cross-over treatment design.
To perform the experiment, we will recruit 160 participants (80 with neuropathic pain and 80 with FM) from the Departments of pain management and research at St Olav's University Hospital and Oslo University Hospital (OUS). The proposed design will be able to determine whether or not executive control, processing speed and memory function differs in two distinct populations of pain patients. Moreover, whether impairments are amended by computerized training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed diagnosis of fibromyalgia or neuropathic pain
- •Confirmed objective cognitive impairments on the CANTAB battery compared to IQ control
排除标准
- •Mania, suicidal ideation and/or active psychosis
- •No objective cognitive impairments
- •Personality disorders
- •Pregnancy
研究组 & 干预措施
Intervention
Working Memory Training
干预措施: Working Memory Training (Behavioral)
Control
Internet use
干预措施: Internet use (Behavioral)
结局指标
主要结局
Objective neuropsychological tests
时间窗: 36 weeks
CANTAB test battery
次要结局
- Sleep duration, quality and awakening(36 weeks)
- Quality of life(36 weeks)
- Medication use(36 weeks)
- Stress regulation(36 weeks)
- Self-reported memory and concentration impairments(36 weeks)
- Pain intensity(36 weeks)
- Symptoms of depression(36 weeks)
- Self-reported cognitive intrusion(36 weeks)
研究者
Henrik Børsting Jacobsen
Post Doctoral Fellow
Oslo University Hospital