Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- Change in forearm vascular conductance with intra-arterial drug infusion
研究概览
简要总结
Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. This project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-45 years of age (premenopausal)
- •Healthy weight (BMI ≥18 and ≤25 kg/m2)
- •Obese (BMI ≥30 kg/m2)
排除标准
- •Pregnancy, breastfeeding, oral hormonal contraceptive use
- •Diagnosed sleep apnea or Oxygen desaturation index >10 events/hr
- •Current smoking/Nicotine use
- •Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
- •Diabetes, Polycystic ovarian syndrome
- •Communication barriers
- •Prescription medications, Sensitivity to lidocaine
结局指标
主要结局
Change in forearm vascular conductance with intra-arterial drug infusion
时间窗: Continuous measurement of vascular conductance during infusion of each drug (final 3 min of normoxia and hypoxia).
Vascular conductance is an index of vascular tone and is measured using a technique called venous occlusion plethysmography.
Change in forearm vascular conductance with cold pressor test
时间窗: Continuous measurement of vascular conductance during cold pressor test (final 2 min of normoxia and hypoxia).
Vascular conductance is an index of vascular tone and is measured using a technique called venous occlusion plethysmography.
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia