The ROAR Study: Reactive Oxygen Species and Reproduction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,100
- 试验地点
- 1
- 主要终点
- Implantation rate
研究概览
简要总结
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 43 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Female age 18-43 years
- •Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
- •Male partners 18 years of age or older.
- •Must be a registered patient at UCSF Center for Reproductive Health
- •Patient and partner must both be physically present on the day of retreival
排除标准
- •Female partner age 44 or older
- •Planning fresh transfer (hybrid PGS cycle)
- •Cleavage stage biopsy
- •Planning to use frozen sperm
研究组 & 干预措施
Couples undergoing IVF
Heterosexual couples undergoing IVF
干预措施: Oxidative stress markers (Diagnostic Test)
结局指标
主要结局
Implantation rate
时间窗: From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved)
Implantation rate of euploid embryos that result from a specific oxidative stress environment
次要结局
未报告次要终点