Propofol Mixed With Lidocaine Versus Lidocaine Pretreatment With Tourniquet for Alleviation of Pain Associated With Propofol Injection
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Verbal Pain Score
研究概览
简要总结
Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Lidocaine pretreatment
Lidocaine pretreatment / saline-propofol admixture
干预措施: lidocaine pretreatment (Drug)
Placebo
Saline pretreatment, saline admixture
干预措施: Saline (Drug)
Lidocaine-Propofol admixture
saline pretreatment / Lidocaine-propofol admixture
干预措施: Lidocaine / propofol admixture (Drug)
结局指标
主要结局
Verbal Pain Score
时间窗: Immediately after injection of study drug. One time assessment.
11 point verbal pain score (VPS) 0=no pain; 10=worst imaginable pain
次要结局
- Satisfaction With Anesthetic Technique(Prior to discharge. One time assessment)
- Complete Alleviation of Injection Pain(Immediately after injection of study drug. One time assessment)
研究者
Joseph Neal
PI
Benaroya Research Institute