The Effect of Barley Beta-glucan on Serum Lipids and Body Weight
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Changes in Body Fat Mass(kg)
研究概览
简要总结
Barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied.
详细描述
This study investigated whether the supplementation of barley β-glucan is reduce the visceral fat as well as the serum low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in mildly hypercholesterolemic subjects. In a 12 week double-blind, controlled study, subjects were randomized to one of treatment group(3.0g/day as β-glucan) or placebo group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •an age from 19 to 70 years,
- •a BMI(Body Mass Index) >23 kg/m^2,
- •an LDL-C(Low Density Lipoprotein-cholesterol) concentration between 110 and 250 mg/dL
排除标准
- •they had heart disease, liver or kidney disease, food allergies, daily exercise habits, a body weight increase or decrease >10 kg in the previous 3 months, irregular lifestyle habits
- •they took medication and functional foods known to affect lipid metabolism.
研究组 & 干预措施
Placebo
Placebo for 12 weeks
干预措施: Placebo (Dietary Supplement)
Barley beta-glucan(3.0g)
Barley beta-glucan(3.0g/day) for 12 weeks
干预措施: Barley beta-glucan(3.0g) (Dietary Supplement)
结局指标
主要结局
Changes in Body Fat Mass(kg)
时间窗: 12 weeks
Body fat mass(kg) was measured in study visit 1(0 week) and visit 3(12 week).
Changes in Percent Body Fat(%)
时间窗: 12 weeks
Percent body fat(%) was measured in study visit 1(0 week) and visit 3(12 week).
次要结局
- Changes in Visceral Adipose Tissue(12 weeks)
- Changes in LDL-C (LDL Low Density Lipoprotein-cholesterol)(12 weeks)
- Changes in HDL-C(High Density Lipoprotein-cholesterol)(12 weeks)
- Changes in Total Cholesterol(12 weeks)
- Changes in Triglyceride(12 weeks)
- Changes in FFA(Free Fatty Acid)(12 weeks)
- Changes in Apo-A1(Apolipoprotein A1)(12 weeks)
- Changes in Apo-B(Apolipoprotein B)(12 weeks)
- Changes in Subcutaneous Adipose Tissue(12 weeks)
研究者
Soo-Wan Chae
Clinical Trial Center for Functional Foods
Chonbuk National University Hospital