Effects of Low-volume High-intensity Training Versus Moderate-intensity Continuous Training on Physical Performance in Older Adults With Possible Sarcopenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change from Baseline in time of the The 5 repeated sit-to-stand test after 7 weeks of intervention
研究概览
简要总结
Background: Sarcopenia is an age-related geriatric syndrome characterized by progressive loss of muscle mass and function. Before the diagnosis of sarcopenia, a "possible sarcopenia" stage has been proposed recently, characterized by low muscle strength or poor physical performance, even with normal muscle mass. The definition of "possible sarcopenia" emphasizes the importance of early intervention. Due to the lack of effective pharmaceutical treatments, exercise is recommended as the most available intervention for sarcopenia. High-intensity interval training (HIIT), a time-efficient aerobic training, has gained increasing popularity for its benefits in physiologic outcomes such as muscle strength and physical functions in other populations. However, the benefits of HIIT have not been well-studied following older adults with possible sarcopenia. In the present study, we aim to investigate the effects of a 7-week HIIT and moderate-intensity continuous aerobic training (MICT) on physical performance in older individuals with possible sarcopenia. We hypothesize that HIIT will confer physical benefits over MICT (i.e., traditional endurance exercise) and will be generally well-tolerated in older adults.
Method: The participants will be randomly allocated into the HIIT or MICT group (1:1 ratio). The participants will receive the training 3 times per week over seven weeks. HIIT consists of 5 bouts of interval training intensity with 1-minute-high intensity (76-90% HRmax) and 1-minute recovery per session (total 15 minutes with warm-up and cool-down). MICT will adopt an intensity of 65-70% HRmax training that lasts less than 30 minutes per session (total 25 minutes with warm-up and cool-down). Evaluation will be performed at baseline, after 4 weeks, and 7 weeks of the intervention. The primary outcomes include 10-meter walking test and the five-time chair stand test. The secondary outcomes include grip strength, the functional stretch test; the Exercise Enjoyment Scale and the Physical Activity Enjoyment Scale for affective valence.
Discussion: This is the first study to investigate the effects of low-volume HIIT on physical performance and affective valence in older adults with possible sarcopenia. This study will provide critical evidence to guide early prevention and intervention of exercise regimens for possible sarcopenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •individuals aged 60 years or older, living in the community
- •Able to walk with or without assistive devices
- •Recovery from COVID-19 over two months
- •With a preliminary screening of SARC-F score ≥4 or calf circumference less than 34cm for man, 33cm for woman will be invited to strength and physical performance measurement
- •Handgrip strength less than 28 kg for man, 18 kg for woman and/or gait speed<1m/s and/or 5-time chair stand test ≥12 s.
排除标准
- •Inability to undertake exercise due to neuromuscular and/or musculoskeletal limitations
- •Uncontrolled hypertension (systolic BP>170 or diastolic BP>100 mmHg)
- •Reported chronic cardiopulmonary insufficiency in medical history
- •Reported vital organ failure and malignancy in medical history
- •Cognitive impairments (mini-mental test score<21) with low compliance
- •History of lower limb surgeries, fractures, neurological problems, systemic problems, and any other contraindications for aerobic training will be excluded.
结局指标
主要结局
Change from Baseline in time of the The 5 repeated sit-to-stand test after 7 weeks of intervention
时间窗: Baseline and after 7 weeks of intervention
The 5 repeated sit-to-stand test is a validated way to reflect the lower limb muscle strength and balance ability of the elderly. Subjects are required to complete 5 times of standing up and sitting down as fast as possible without using handrails or other assistance by crossing the arms in front of the chest. Care should be taken to ensure that the knee joints are completely straight before sitting down. The time of completing test will be recorded. Change=(week 7 time- baseline time)
次要结局
- Change from Baseline in score of The Exercise Enjoyment Scale after 7 weeks of intervention(Baseline and after 7 weeks of intervention)
- Change from Baseline in score of The Physical activity enjoyment scale after 7 weeks of intervention(Baseline and after 7 weeks of intervention)
- Change from Baseline in walking speed of the 10 meter-walk test after 7 weeks of intervention(Baseline and after 7 weeks of intervention)
- Change from Baseline in Hand grip strength after 7 weeks of intervention(Baseline and after 7 weeks of intervention)
- Change from Baseline in distance of The functional stretch test after 7 weeks of intervention(Baseline and after 7 weeks of intervention)