Effects of Eccentric Training Intervention in Older Adults

Not Applicable

• Conditions: Sarcopenia
• Interventions: Device: Eccentric exercise; Device: Conventional resistance exercise

• Registration Number: NCT04099316
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Sarcopenia leads to loss of muscle mass and muscle strength during the aging process. It has been reported that eccentric training has some positive effects on the preservation of eccentric strength, with less delayed onset muscle soreness (DOMS) in older groups, and lower metabolic costs.

Detailed Description

This is prospective study. The goals of this study are to:

1. Examine the effects of eccentric training on physical function (gait speed, stair climb, chair stand) in older adults.

2. Examine the effects of eccentric training on muscle strength (Isometric strength, Isokinetic strength, power) in older adults.

Study Timeline

• Study Start: 2017-07-20
• Study First Submitted: 2019-05-16
• Status Verified: 2019-09
• Study First Submitted QC: 2019-09-19
• Last Update Submitted: 2019-09-19
• Study First Posted: 2019-09-23
• Last Update Posted: 2019-09-23
• Primary Completion: 2019-09-30
• Study Completion: 2019-10-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Subjects who can agree voluntarily
• Older men/women: Age (60 - 80 yrs)

Exclusion Criteria

• Uncontrolled hypertension
• Acute coronary syndrome
• Subjects who took drugs which can affects neuromuscular system
• Subjects who cannot agree voluntarily

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Older adults	Eccentric exercise	Older adults (Over the 60 years), Subjects did not suffer from musculoskeletal or metabolic diseases.
Older adults-Control	Conventional resistance exercise	Older adults (Over the 60 years), Subjects did not suffer from musculoskeletal or metabolic diseases.

Primary Outcome Measures

Name	Time	Method
Gait speed	Change from baseline gaitspeed at 8 weeks	An examiner used a stopwatch to time how long it took subjects to walk along a marked tape. The Kinect device was used to measure gait speed.
Stair climb	Change from baseline stair climb at 8 weeks	Subjects were measured on eight 17-cm stairs twice, requiring a step by step pattern, where the timer activated when the first contact was made at the first step and ended when the contact occurred at the last step before and after the 8 weeks of exercise training.
Chair stand	Change from baseline chair stand at 8 weeks	Subjects had to get up from a chair measuring 41 cm in height with a flat seat. Subjects were asked to stand up and sit down 5 times as quickly as possible with their arms folded across the chest. They stood up until full extension was observed at the trunk and lower limb joints, and returned to a seated position with their back fully supported at the back of the chair.

Secondary Outcome Measures

Name	Time	Method
Isokinetic knee strength	Change from baseline isokinetic knee strength at 8 weeks	The isokinetic was measured using a baltimore therapeutic equipment (BTE) Primus RS (BTE Tech., Hanover, MD, USA). The subject performed a 60 degree per second knee flexion and extension five times. Each isokinetic contraction was performed through a full range of motion.Before each subject began the isokinetic test, the subject warmed up using a 50-60% knee extension/flexion once.; Isokinetic knee strength is measured in as peak torque achieved on an isokinetic dynamometer (BTE PrimusRS, BTE tech, MD, USA) at 60 degree per second.
Isometric knee strength	Change from baseline isometric knee strength at 8 weeks	Isometric knee strength was measured using a baltimore therapeutic equipment (BTE) Primus RS (BTE Tech., Hanover, MD, USA). The subject was asked to sit on the treatment chair and a standard stabilization strap was placed on the upper ankle. The knee was kept at 90 degree flexion, and the foot was positioned in dorsi flexion. The subject's hands were placed on the edge of the side of the chair and the trunk, hips, and mid-thigh were stabilized in the chair by the straps.
Power	Change from baseline power at 8 weeks	The test used same machine as the isometric and isokinetic tests. The ankle was placed in a neutral position, and the subjects performed a range of motion for 10 seconds, once. After the warm up, knee extension and flexion were performed as quickly as possible during a period of 10 seconds.; Isokinetic knee strength is measured in as peak torque achieved on an isokinetic dynamometer (BTE PrimusRS, BTE tech, MD, USA) at 60 degree per second.

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Geyonggi, Korea, Republic of