Resistance Training for Life - the Efficacy of Increasing Resistance Training Volume for Improving Muscle Mass, Function, Biology and Health in Young and Elderly
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Sarcopenia
- Sponsor
- Stian Ellefsen
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- Muscle size, lower extremities
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Sarcopenia is an age-related gradual loss of muscle mass and strength and is associated with physical disability and mortality risk. Currently, the most promising remedy for preventing and treating sarcopenia is physical activity, particularly progressive resistance training. Yet, the amount of resistance exercise needed to achieve optimal benefits remains largely unknown. This lack of knowledge is underpinned by the notion that aging reduces the ability to adapt to (and benefit from) resistance training, and is further complicated by a relative large degrees of between-subject heterogeneity. The primary aim of the study is to compare the effects of 10 weeks of resistance training with low- and moderate volume (one vs. three sets per exercise) on muscle mass accretion in lower and upper body extremities in young (<30 years of age) and elderly individuals (>70 years of age). Specifically, the study addresses the hypothesis that elderly individuals will benefit more from higher exercise volume (moderate vs. low) compared to their young counterparts. In addition, the study aims to compare the efficacy of the two volume conditions for altering other characteristics such as muscle strength and biology, including assessment of associations between individual changes in muscle mass, strength and biology (e.g. the relationship between muscle mass accretion and muscle content of rRNA/rDNA), and also to investigate the general health effects of the intervention.
Investigators
Stian Ellefsen
Professor
Inland Norway University of Applied Sciences
Eligibility Criteria
Inclusion Criteria
- •Ages between 18 and 30 or \> 70
Exclusion Criteria
- •Resistance training, \> 1 session per week
- •Endurance training, \> 3 sessions per week
- •Unstable cardiovascular disease
- •Illness or serious injury contradicting resistance training
- •Serious mental illness
- •Allergy to local anaesthesia
Outcomes
Primary Outcomes
Muscle size, lower extremities
Time Frame: Change from baseline to after the training period (10-12 weeks)
Muscle size of lower extremity knee extensors measured with magnetic resonance imaging (MRI).
Secondary Outcomes
- Muscular peak power/force, lower-body extremities(MeasurChange from baseline to after the training period (10-12 weeks))
- Muscle size, upper-body extremities(Change from baseline to after the training period (10-12 weeks))
- Appendicular lean mass, lower-body extremities(Change from baseline to after the training period (10-12 weeks))
- Appendicular lean mass, upper-body extremities(Change from baseline to after the training period (10-12 weeks))
- Muscle thickness, m. vastus lateralis(Change from baseline to after the training period (10-12 weeks))
- Muscle strength, lower-body extremities(Change from baseline to after the training period (10-12 weeks))
- Muscle strength, upper-body extremities(Change from baseline to after the training period (10-12 weeks))