Exploring the Antecedents and Consequences of Cannabis Use in the Context of Coping: An Experimental Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 166
- 试验地点
- 1
- 主要终点
- Blood Cortisol Levels
研究概览
简要总结
The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate.
We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •21-65 years of age
- •Endorsement of at least some use of cannabis for coping purposes (>1 on CMMQ)
- •Regularly use flower cannabis products (i.e., ≥1x/week in the last 6 months)
- •Proficient in English language
- •At least occasional use of CBD+THC or CBD-dominant products (e.g., ≥1x/month)
排除标准
- •Diagnosis or use of medications for substance use or psychotic disorders
- •Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs
- •Females cannot be pregnant or trying to become pregnant or nursing mothers
- •Not able to provide informed consent
研究组 & 干预措施
Warm Water
干预措施: Water Temperature Variation - WW (Other)
Cold Water
干预措施: Water Temperature Variation - CW (Other)
结局指标
主要结局
Blood Cortisol Levels
时间窗: Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use
Cortisol levels are measured in blood.
Cannabis Used
时间窗: Immediate Post-Use
Grams of product used is calculated. Product is measured before and after use to measure how much was used.
Blood Endocannabinoid Levels
时间窗: Pre-Use/Pre-Water Task, 20 minutes Post-Use
Blood levels of AEA are measured.
Heart Rate
时间窗: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use
Participant HR is measured via pulse oximeter.
Social Anxiety
时间窗: Pre-Use/Pre-Water Task
Social Interaction Anxiety Scale (SIAS). 20 item survey, questions are answered on scale of 0 (not at all) to 4 (extremely), with higher scores indicating higher social anxiety. Questions are summed, with higher overall scores indicating higher social anxiety.
Inhibitory Control
时间窗: Baseline
Go/No-go Task. Participants are asked to complete a cognitive task where they see the text "Go" or "No go" during different trials. When they see "Go", they need to push a button within 2 seconds. When they see "No-go", they need to make sure they do not press the button (for 2 seconds). This is a measure of impulsivity.
Stress
时间窗: Pre-Use/Pre-Water Task
Stress Subscale of Depression and Anxiety Stress Scale measures stress. On scale from 0 (does not apply to me at all) to 3 (apply to me very much or most of the time). Higher scores indicate higher stress levels.
Blood cannabinoid levels
时间窗: Pre-Use/Pre-Water Task, 20 minutes Post-Use
THC and CBD blood levels are measured.
Current Pain
时间窗: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use
Internal scale/measure, measured from 0 (no pain) to 10 (worst pain imaginable). Participants report current pain on this self-report scale.
Mood
时间窗: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use
Profile of Mood States (POMS). Focus on the stress, anxiety, tension, and relaxation questions (combined for a tension/anxiety subscale). Questions are on a scale 1 (not at all) to 5 (extremely). Scores are summed, with higher scores indicating more tension/anxiety.
次要结局
未报告次要终点
研究者
Carillon Skrzynski
Research Assistant Professor
University of Colorado, Boulder