Role of Auditory Cortical Oscillations in Speech Processing and Its Dysfunction in Dyslexia Through Transcranial Alternating Current Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Changes in linguistic performance through a battery of behavioral tests
研究概览
简要总结
This study aims at investigating the role of low-gamma activity in phonemic encoding and its implication in dyslexia. Indeed, a phonological deficit, i.e. a difficulty in perceiving the sounds of speech, is strongly suspected in dyslexia but has never been conclusively associated with a specific underlying mechanism.
The study employs transcranial alternating current stimulation in adults with and without dyslexia to exploit the effect of the stimulation on phonemic processing and neural activity measured with electroencephalography. In doing so, it would be possible to establishing a causal link between gamma oscillations and the phonological deficit in dyslexia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
One of three different tACS conditions is administered to all participant during three experimental days. The conditions differ in the frequency of stimulation (condition 1 and 2) and in whether the stimulation is active or faked (sham). The order of the three stimulation conditions is counterbalanced across participants, who are not aware of which tACS condition they are undergoing.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-65 years old;
- •French native speakers;
- •normally-hearing;
- •intellectual quotient (IQ) around average;
- •for the dyslexia group: previous diagnosis of dyslexia as assessed by a speech therapist.
排除标准
- •Presence of metal or electronic implants in the brain/skull;
- •Presence of metal or electronic device at other in other parts of the body;
- •Have experienced a seizure or a loss of consciousness or a severe head trauma;
- •Severe brain related illness ;
- •Intake of central nervous system-effective medication;
- •Pregnant and nursing women;
- •Relatives affected by epilepsy.
结局指标
主要结局
Changes in linguistic performance through a battery of behavioral tests
时间窗: 6 hours
Measurement of phonemic and syllabic processing (pseudoword repetition and spoonerism test), and reading (reading a 3 min. text, both accuracy and reading speed are considered) skills. These tests are repeated before, after and 1h after the tACS stimulation.
Measure low-gamma neural oscillations with electroencephalography recordings
时间窗: 6 hour
Auditory-steady state responses to auditory stimuli are measured to assess specific differences between individuals with dyslexia and normo-readers, and between the different tACS stimulation conditions before, after and 1h after the 20 min. tACS stimulation. These neural correlated are estimated by considering the power of EEG signal at the frequency used to modulate the auditory stimuli.
次要结局
未报告次要终点
研究者
Anne-Lise Giraud
Professor
University of Geneva, Switzerland