NCT06315504尚未招募不适用
Circulating Factors in Nephrotic Syndrome - A Prospective Observational Cohort Study
Iain Bressendorff0 个研究点目标入组 104 人开始时间: 2024年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 104
- 主要终点
- levels of anti-nephrin in blood by ELISA
研究概览
简要总结
A prospective observational study to investigate the treatment-associated changes of circulating factors associated with glomerular diseases among patients with de novo nephrotic syndrome admitted to hospital for a kidney biopsy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Plasma albumin < 36 g/L
- •Urine protein >3.5 g/day or urine protein/creatinine-ratio (UPCR) > 3.5 or urine albumin/creatinine-ratio (UACR) >2200 mg/g
- •Planned kidney biopsy
- •Able to give written informed consent
排除标准
- •Kidney transplant recipient
- •Previously undergone a kidney biopsy
- •Unable to understand written information in Danish
结局指标
主要结局
levels of anti-nephrin in blood by ELISA
时间窗: up to 12 months
temporal association of anti-nephrin with clinical remission of nephrotic syndrome
次要结局
- changes in auto-antibodies in blood associated with membranous nephropathy(up to 24 months)
研究者
Iain Bressendorff
MD PhD
Herlev Hospital
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