aMsa and amiOdarone Study in cArdiaC Arrest
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 629
- 试验地点
- 4
- 主要终点
- AMSA values
研究概览
简要总结
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA).
Amiodarone is recommended for the treatment of cardiac arrest due to ventricular tachycardia/ventricular fibrillation (VT/VF) ( with a low level of recommendation cause of conflicting results. AMSA is a parameter expressing the amplitude of VF and it has been shown to predict defibrillation success and the return of spontaneous circulation (ROSC). No data are available so far about the impact of amiodarone administration on AMSA values.
详细描述
The primary study endpoint of the present study is to determine whether patients who received amiodarone during advanced resuscitation had lower values of AMSA as compared to those who did not receive amiodarone.
Secondary endpoints
The secondary endpoints of this study are:
- To assess, after correction for confounders, the rate of successful defibrillation, the rate of ROSC and the rate of short-term survival (survived event or survival to hospital discharge according to the available data) both in the amiodarone and non-amiodarone group.
- To assess the role of AMSA for shock success and ROSC prediction in amiodarone group and in non-amiodarone group.
Type of study. This is a multicentre study based on a retrospective analysis of prospectically collected data.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Year 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with out-of-hospital cardiac arrest
- •shockable presenting rhythm
- •resuscitation attempted
- •advanced resuscitation attempted
- •technical: - VF cardiac arrest (and not VT)
排除标准
- •non-shockable presenting rhythm
- •resuscitation not attempted
- •AMSA not evaluable
研究组 & 干预措施
Amiodarone group
Patients who did receive amiodarone during the attempt of resuscitation
干预措施: Amiodarone Injection (Drug)
结局指标
主要结局
AMSA values
时间窗: through study completion, an average of 1 year
to determine whether AMSA values in the Amiodarone group are lower than in the NO Amiodarone gorup
次要结局
- Successful defibrilaltion(through study completion, an average of 1 year)
- Survived event(through study completion, an average of 1 year)
- ROSC(through study completion, an average of 1 year)
- Survival to hospital discharge(through study completion, an average of 1 year)
- Prediction(through study completion, an average of 1 year)
研究者
Simone Savastano
principal investigator
Fondazione IRCCS Policlinico San Matteo di Pavia