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临床试验/NCT07766720
NCT07766720招募中不适用

Effects of NEM® Brand Eggshell Membrane and curQ+® Brand Highly Absorbable Curcumin Supplementation, Alone or in Combination, on Recovery From Intense Exercise in Recreationally Active Men.

ESM Technologies, LLC1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2026年2月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
60
试验地点
1
主要终点
VAS Muscle Soreness Rating

研究概览

简要总结

Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients affects recovery from intense exercise.

详细描述

Eggshell membrane (EM) is derived from the inner fibrous layer of eggs that contain a number of proteins and Types I, V, and X collagen and sulfur containing amino acids (i.e., e.g., methionine, cysteine), glycosaminoglycans (e.g., hyaluronic acid, dermatan sulfate, chondroitin sulfate) that are found in synovium, cartilage, ligaments, and tendons of human joint tissue. Initial studies have shown that EM supplementation reduces inflammation and perception of pain while improving markers of joint health in individuals with osteoarthritis. Curcumin (Curcuma longa) is a member of the ginger family (Zingiberaceae) that contains polyphenols that have anti-inflammatory properties. Studies show that curcumin (Curc) can reduce inflammation related to osteoarthritis, exercise, concussion and traumatic brain injury. Theoretically, EM and Curc supplementation prior to intense exercise may reduce inflammation, perceptions of muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients (NEM® brand eggshell membrane and curQ+® brand highly absorbable curcumin) separately and in combination affects recovery from intense exercise in recreationally active men.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Male
接受健康志愿者
是

入选标准

  • •Age 18 to 40 at the time of consent.
  • •Healthy and recreationally active.
  • •Ability to comply with study procedures.
  • •Agree to refrain from alcohol intake and use of non-steroidal anti-inflammatory (NSAIDS), aspirin, and other over-the-counter pain medications for 48 hours prior to and after completion of each testing session.

排除标准

  • •No recent history of exercise training
  • •An orthopedic limitation that would prevent the ability to perform the exercise intervention.
  • •Participants who currently smoke cigarettes.
  • •Known allergies to eggs, sulfur, or curcumin.

研究组 & 干预措施

Active, EM

Experimental

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.

干预措施: NEM® brand eggshell membrane powder (Dietary Supplement)

Active, EM

Experimental

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.

干预措施: Curc Placebo (Dietary Supplement)

Active, curc

Experimental

2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

干预措施: curQ+® brand highly absorbable curcumin (Dietary Supplement)

Active, curc

Experimental

2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

干预措施: EM Placebo (Dietary Supplement)

Placebo

Placebo Comparator

500 mg/day of psyllium husk fiber powder in a single #0 capsule PLUS 2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.

干预措施: EM Placebo (Dietary Supplement)

Placebo

Placebo Comparator

500 mg/day of psyllium husk fiber powder in a single #0 capsule PLUS 2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.

干预措施: Curc Placebo (Dietary Supplement)

Active, EM+Curc

Experimental

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

干预措施: NEM® plus curQ+® combination (Dietary Supplement)

结局指标

主要结局

VAS Muscle Soreness Rating

时间窗: 2 weeks

Changes in Visual Analog Scale (VAS) ratings of muscle soreness (rated from zero to 100 mm) from baseline following intense exercise. The higher the rating, the more muscle soreness so negative changes in VAS would equate to improvement.

次要结局

  • Urinary CTX-II(2 weeks)
  • Muscle Damage(2 weeks)
  • Exercise Performance(2 weeks)
  • Inflammation Biomarkers(2 weeks)

研究者

申办方类型
Industry
责任方
Sponsor

研究点 (1)

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