The Effects of Cranberry Juice on Urine and Bacterial Adhesion to Cells
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 主要终点
- bacterial adhesion to tissue cells
研究概览
简要总结
The study is based on the hypothesis that consumption of cranberry juice products results in the production of metabolites in the urine that have anti-adhesive properties on bacteria. A crossover study using 12 healthy women will be given different cranberry products or water as a control and their urine will be analyzed for anti-adhesive effects and compared to the properties of the urine. Cranberry juice will also be evaluated for its effect on vaginal microflora.
详细描述
Hypothesis: Metabolites in cranberry juice, have anti-adhesive properties for uropathogenic bacteria but they do not disturb the normal vaginal flora.
Study design and assays:
A crossover study design using 12 healthy women will be conducted for 50 days. The anti-adhesive properties of the urine will be determined using uropathogens and changes in the vaginal microflora will be evaluated.
Participants:
The subjects will be healthy premenopausal women aged 19-45, who have no history of chronic urinary tract infection or have had a urinary tract infection in the past 12 months, and are currently not taking antibiotics or any supplements to prevent UTI, including cranberry juice. The subjects must not have urinary tract abnormalities, requiring catheterization for micturition, be pregnant, or diabetic or have allergies to berry juices. Each test phase is 1 week (7 days) and the following protocol will be followed:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 19 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age 19-45 years
- •Healthy pre-menopausal female volunteers with no history of urinary tract infections over the past 12 months.
排除标准
- •Experienced a urinary tract infection in the past 12 months
- •Receiving antibiotic therapy or supplements to prevent urinary tract infections
- •Pregnant, postmenopausal or outside of the age range (19-45 years old)
- •Anatomical abnormality of the urinary tract, such as following surgery
- •Using a catheter to manage micturition
- •Allergic to berry juices
结局指标
主要结局
bacterial adhesion to tissue cells
microbial population shifts in vaginal tract
次要结局
未报告次要终点