ISRCTN68035289已完成未知
Effect of thienopyridine derivative (clopidogrel) on the disposition of efavirenz and neviparine in human immunodeficiency virus (HIV) positive patients: a randomised single-phase multi-dose proof-of-concept study
Royal Liverpool University Hospital and the University of Liverpool?s Biomedical Research Centre (UK)0 个研究点目标入组 37 人开始时间: 2009年12月17日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 37
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged greater than 18 years, either sex
- •2. On efavirenz (EFV) or nevirapine (NVP) containing regimen for greater than or equal to 6 months
- •3. Viral load less than or equal to 40 copies/ml and any CD4 count
- •4. No laboratory evidence of NNRTI toxicity:
- •4.1. Alanine aminotransferase (ALT) less than or equal to upper limit of normal (ULN)
- •4.2. Bilirubin less than or equal to ULN
- •4.3. Albumin greater than or equal to 30 g
- •4.4. Creatinine less than or equal to ULN
- •5. Not pregnant (for contraception, patients would be advised to use non-oestrogen based contraceptive devices)
- •6. No inter-current acute illness
- •7. No past medical history of coronary heart disease
- •8. No history of bleeding diathesis
- •9. No history of allergy to thienopyridines
排除标准
- •1. Unable to provide informed consent
- •2. Known or suspected poor adherence to anti-retroviral therapy (ART)
- •3. Continuing intravenous (IV) drug user
- •4. On a HIV protease inhibitor or any known P450 inhibitors or inducers
- •5. Platelets less than or equal to 100 x 10^9/l
- •6. Neutrophils less than or equal to 1.0 x 10^9/ml
研究者
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