NCT03044561Unknown4 期
Effect of Sildenafil Citrate on the Outcome of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- endometrial thickness measures
研究概览
简要总结
The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF
详细描述
sildenafil citrate may increase endometrial thickness in women with recurrent IVF failure attributed to poor endometrial development
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •(1) cases of infertility, older than 20 years of age and not older than 40 years.
- •(2) Body mass index (BMI):20-
- •(3) women have experienced two or more implantation failure attributed to inadequate endometrial development.
排除标准
- •(1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome).
- •(2) Any contraindication to sildenafil citrate or any of the components of its formulation including:
- •Concurrent use of organic nitrites and nitrates.
- •Severe hepatic impairment.
- •Severe renal impairment.
- •Hypotension.
- •Recent stroke or heart attack.
研究组 & 干预措施
Sildenafil citrate
Experimental
干预措施: Sildenafil Citrate (Drug)
placebo
Placebo Comparator
干预措施: matching placebo (Drug)
结局指标
主要结局
endometrial thickness measures
时间窗: 21 days
we will measure endometrial thickness by US in women with recurrent implantation failure
次要结局
未报告次要终点
研究者
Amr El-Sayed
principal investigator
Ain Shams University
研究点 (1)
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